Issue 18, 2023

The crucial role of silver(i)-salts as additives in C–H activation reactions: overall analysis of their versatility and applicability

Abstract

Transition-metal catalyzed C–H activation reactions have been proven to be useful methodologies for the assembly of synthetically meaningful molecules. This approach bears intrinsic peculiarities that are important to be studied and comprehended in order to achieve its best performance. One example is the use of additives for the in situ generation of catalytically active species. This strategy varies according to the type of additive and the nature of the pre-catalyst that is being used. Thus, silver(I)-salts have proven to play an important role, due to the resulting high reactivity derived from the pre-catalysts of the main transition metals used so far. While being powerful and versatile, the use of silver-based additives can raise concerns, since superstoichiometric amounts of silver(I)-salts are typically required. Therefore, it is crucial to first understand the role of silver(I) salts as additives, in order to wisely overcome this barrier and shift towards silver-free systems.

Graphical abstract: The crucial role of silver(i)-salts as additives in C–H activation reactions: overall analysis of their versatility and applicability

Article information

Article type
Review Article
Submitted
01 Mei 2023
First published
01 Sep 2023
This article is Open Access
Creative Commons BY license

Chem. Soc. Rev., 2023,52, 6359-6378

The crucial role of silver(I)-salts as additives in C–H activation reactions: overall analysis of their versatility and applicability

R. L. de Carvalho, E. B. T. Diogo, S. L. Homölle, S. Dana, E. N. da Silva Júnior and L. Ackermann, Chem. Soc. Rev., 2023, 52, 6359 DOI: 10.1039/D3CS00328K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements