Issue 24, 2023

Lanthanide-based luminescent probes for biological magnesium: accessing polyphosphate-bound Mg2+

Abstract

Biomolecule-bound Mg2+ species, particularly polyphosphate complexes, represent a large and dynamic fraction of the total cellular magnesium that is essential for cellular function but remains invisible to most indicators. Here we report a new family of Eu(III)-based indicators, the MagQEu family, functionalized with a 4-oxo-4H-quinolizine-3-carboxylic acid metal recognition group/sensitization antenna for turn-on, luminescence-based detection of biologically relevant Mg2+ species.

Graphical abstract: Lanthanide-based luminescent probes for biological magnesium: accessing polyphosphate-bound Mg2+

Supplementary files

Article information

Article type
Communication
Submitted
31 Des 2022
Accepted
27 Feb 2023
First published
28 Feb 2023

Chem. Commun., 2023,59, 3586-3589

Author version available

Lanthanide-based luminescent probes for biological magnesium: accessing polyphosphate-bound Mg2+

B. Pinto-Pacheco, Q. Lin, C. W. Yan, S. de Melo Silva and D. Buccella, Chem. Commun., 2023, 59, 3586 DOI: 10.1039/D2CC07095B

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