Issue 30, 2022

Metal–organic frameworks as a therapeutic strategy for lung diseases

Abstract

Lung diseases remain a global burden today. Lower respiratory tract infections alone cause more than 3 million deaths worldwide each year and are on the rise every year. In particular, with coronavirus disease raging worldwide since 2019, we urgently require a treatment for lung disease. Metal organic frameworks (MOFs) have a broad application prospect in the biomedical field due to their remarkable properties. The unique properties of MOFs allow them to be applied as delivery materials for different drugs; diversified structural design endows MOFs with diverse functions; and they can be designed as various MOF-drug synergistic systems. This review concentrates on the synthesis design and applications of MOF based drugs against lung diseases, and discusses the possibility of preparing MOF-based inhalable formulations. Finally, we discuss the chances and challenges of using MOFs for targeting lung diseases in clinical practice.

Graphical abstract: Metal–organic frameworks as a therapeutic strategy for lung diseases

Article information

Article type
Review Article
Submitted
29 Mac 2022
Accepted
20 Jun 2022
First published
27 Jun 2022

J. Mater. Chem. B, 2022,10, 5666-5695

Metal–organic frameworks as a therapeutic strategy for lung diseases

Y. Zheng, Y. Zhao, M. Bai, H. Gu and X. Li, J. Mater. Chem. B, 2022, 10, 5666 DOI: 10.1039/D2TB00690A

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