Issue 24, 2022

Modern metal-catalyzed and organocatalytic methods for synthesis of coumarin derivatives: a review

Abstract

Coumarin is an important pharmaceutical structural motif, abundantly found in numerous commonly used drugs. Compounds containing this core show a broad spectrum of medicinal properties and biological activities. The increasing importance and wide usages of coumarin derivatives have drawn attention to its synthetic methods, among which metal-catalyzed and organocatalytic methods have proved the most effective. Several metal-catalyzed and/or organocatalytic synthetic strategies for coumarin have been investigated and reported in recent decades. This review focuses on more recent reports on catalysis methods for synthesizing coumarin and coumarin-like structures (including light-mediated methods and nano-catalysts), exploring the mechanistic aspects, simplicity, efficiency, repeatability, and other advantages and disadvantages of these methods.

Graphical abstract: Modern metal-catalyzed and organocatalytic methods for synthesis of coumarin derivatives: a review

Article information

Article type
Review Article
Submitted
13 Mac 2022
Accepted
02 Mei 2022
First published
02 Mei 2022

Org. Biomol. Chem., 2022,20, 4846-4883

Modern metal-catalyzed and organocatalytic methods for synthesis of coumarin derivatives: a review

S. Moghadam Farid, B. Seifinoferest, M. Gholamhosseyni, B. Larijani and M. Mahdavi, Org. Biomol. Chem., 2022, 20, 4846 DOI: 10.1039/D2OB00491G

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