Issue 11, 2022

Deep eutectic solvents meet safe, scalable and sustainable hydrogenations enabled by aluminum powder and Pd/C

Abstract

A general, safe and scalable reductive protocol, based on the in situ generation of H2 from aluminum and water, has been developed in deep eutectic solvents for the reduction of many organic compounds under Pd-catalysis. The methodology has been efficiently applied to the multigram-scale synthesis of benzindopyrine as an active pharmaceutical ingredient.

Graphical abstract: Deep eutectic solvents meet safe, scalable and sustainable hydrogenations enabled by aluminum powder and Pd/C

Supplementary files

Article information

Article type
Communication
Submitted
16 Feb 2022
Accepted
28 Apr 2022
First published
03 Mei 2022

Green Chem., 2022,24, 4388-4394

Deep eutectic solvents meet safe, scalable and sustainable hydrogenations enabled by aluminum powder and Pd/C

F. Messa, G. Dilauro, A. N. Paparella, L. Silvestri, G. Furlotti, T. Iacoangeli, S. Perrone and A. Salomone, Green Chem., 2022, 24, 4388 DOI: 10.1039/D2GC00636G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements