Issue 90, 2022

Synthetic applications of NHPs: from the hydride pathway to a radical mechanism

Abstract

The unique heterocyclic skeletons of N-heterocyclic phosphines (NHPs) endow them with excellent hydridic reactivity, which has enabled NHPs to be applied in a great array of catalytic hydrogenations of unsaturated substrates in the past few decades. Recently, applications of NHPs in radical reductions, especially in a catalytic fashion, have emerged as a promising forefront area. This new reaction pattern, distinctive from but complementary to the well-established hydride pathway, can greatly expand the reaction scope to σ-bond scission. Herein, we briefly summarized some representative examples of synthetic applications of NHPs in both hydridic and radical reductions with an emphasis on their radical reactivity, including the structural and property studies of NHP radicals and their precursors as well as their applications in radical processes.

Graphical abstract: Synthetic applications of NHPs: from the hydride pathway to a radical mechanism

Article information

Article type
Feature Article
Submitted
01 Sep 2022
Accepted
06 Okt 2022
First published
07 Okt 2022

Chem. Commun., 2022,58, 12528-12543

Synthetic applications of NHPs: from the hydride pathway to a radical mechanism

Y. Zhang, Z. Huan, J. Yang and J. Cheng, Chem. Commun., 2022, 58, 12528 DOI: 10.1039/D2CC04844B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements