Issue 17, 2022

Cationic AIEgen micelle-improved chemiluminescent H2O2 assay by integrating reactant approach and CRET

Abstract

The enhancement of chemiluminescence (CL) intensity is significant in the development of chemiluminescent detection systems with improved sensitivity. In this study, a cationic surfactant with an intrinsic aggregation-induced emission emitter (AIEgen) has been applied to boost the CL signal of the horseradish peroxidase-luminol-H2O2 system. The formed cationic AIEgen micelles enhance the CL signal in two ways: the electrostatic attraction-mediated enrichment and approach of reactants and the high CRET efficiency between excited luminol radicals and AIEgen in the surfactant backbone. As a result, strong CL intensity is produced. Rapid and sensitive H2O2 detection is realized through the proposed cationic AIEgen micelle-containing chemiluminescent system with a limit of detection of 100 nM. The favourable selectivity over other possible interferents including metal ions and anions is due to the specific chemical reaction. Practical H2O2 analysis of thawing water samples with high accuracy using the proposed chemiluminescent platform is realized and is consistent with standard methods.

Graphical abstract: Cationic AIEgen micelle-improved chemiluminescent H2O2 assay by integrating reactant approach and CRET

Supplementary files

Article information

Article type
Paper
Submitted
03 Mac 2022
Accepted
31 Mac 2022
First published
31 Mac 2022

Anal. Methods, 2022,14, 1671-1677

Cationic AIEgen micelle-improved chemiluminescent H2O2 assay by integrating reactant approach and CRET

Y. Yu, W. Guan, Z. Yuan and C. Lu, Anal. Methods, 2022, 14, 1671 DOI: 10.1039/D2AY00372D

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