Issue 5, 2021
From the journal:

RSC Chemical Biology

Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines†

Weifeng Lin, ORCID logo a   Zhen Yang,a   Amanpreet Kaur, ORCID logo a   Annika Block,a   Miroslav Vujasinovic,b   J.-Matthias Löhrbc  and  Daniel Globisch ORCID logo *a  

* Corresponding authors

a Department of Chemistry–BMC, Science for Life Laboratory, Uppsala University, Box 599, Uppsala SE-75124, Sweden
E-mail: Daniel.globisch@scilifelab.uu.se

b Department for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden

c Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute, Stockholm, Sweden

Abstract

The investigation of microbiome-derived metabolites is important to understand metabolic interactions with their human host. New methodologies for mass spectrometric discovery of undetected metabolites with unknown bioactivity are required. Herein, we introduce squaric acid as a new chemoselective moiety for amine metabolite analysis in human fecal samples.

Graphical abstract: Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D1CB00132A
Article type
Communication
Submitted
15 Jun 2021
Accepted
10 Aug 2021
First published
12 Aug 2021
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2021,2, 1479-1483

Permissions

Request permissions

Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines

W. Lin, Z. Yang, A. Kaur, A. Block, M. Vujasinovic, J.-Matthias Löhr and D. Globisch, RSC Chem. Biol., 2021, 2, 1479 DOI: 10.1039/D1CB00132A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements