Issue 53, 2019

In vitro study of chitosan-based multi-responsive hydrogels as drug release vehicles: a preclinical study

Abstract

Systematic administration of painkillers and anti-inflammatory drugs is routinely employed to minimize pain and bodily disorders. Controlled drug delivery has the potential to improve the outcomes of disorders by providing sustained exposure to efficacious drug concentrations. Herein, we report the fabrication of multi-responsive hydrogels using reactive and functional polymers such as chitosan and polyvinyl pyrrolidone by varying the concentration of a cleavable crosslinker, tetraethyl orthosilicate. The swelling indices of the hydrogels were evaluated in distilled water, solutions with different pH values and different electrolytes. FTIR, WAXRD and TGA were conducted to investigate the structures, crystallinities and thermal stabilities of the prepared multi-responsive hydrogels, respectively. The ultimate tensile strength and elongations at break of the fabricated hydrogels were investigated to assess their mechanical stability. Optical microscopy, biodegradation, antimicrobial and cytotoxicity analyses were further carried out to verify the magnified crosslinked and porous structures, biodegradabilities, biocompatibilities and toxic behaviour of the as-prepared hydrogels, respectively. Drug release analysis was conducted to evaluate their release behaviour in PBS, SGF, SIF and electrolyte solutions. The overall results indicate the successful development of novel, non-toxic and sustained drug deliverable hydrogels, which can be considered as a paramount success towards the fabrication of controlled drug delivery systems.

Graphical abstract: In vitro study of chitosan-based multi-responsive hydrogels as drug release vehicles: a preclinical study

Article information

Article type
Paper
Submitted
03 Jul 2019
Accepted
01 Sep 2019
First published
01 Okt 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 31078-31091

In vitro study of chitosan-based multi-responsive hydrogels as drug release vehicles: a preclinical study

N. Gull, S. M. Khan, M. T. Zahid Butt, S. Khalid, M. Shafiq, A. Islam, S. Asim, S. Hafeez and R. U. Khan, RSC Adv., 2019, 9, 31078 DOI: 10.1039/C9RA05025F

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