Issue 8, 2018

Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa

Abstract

The opportunistic human pathogen Pseudomonas aeruginosa secretes 2-heptyl-3-hydroxy-4-quinolone (PQS), a quorum sensing (QS) signal that regulates the expression of numerous virulence genes. Here we report the development and application of chemical probes to globally map quinolone binding proteins. The revealed quinolone interactome contains both known as well as newly identified virulence factors and presents new targets for the treatment of bacterial infections.

Graphical abstract: Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa

Supplementary files

Article information

Article type
Edge Article
Submitted
02 Okt 2017
Accepted
19 Jan 2018
First published
19 Jan 2018
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2018,9, 2290-2294

Proteome-wide mapping of PQS-interacting proteins in Pseudomonas aeruginosa

R. Dandela, D. Mantin, B. F. Cravatt, J. Rayo and Michael M. Meijler, Chem. Sci., 2018, 9, 2290 DOI: 10.1039/C7SC04287F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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