Issue 11, 2018

Direct functionalization of benzylic and non-benzylic C(sp3)–H bonds via keteniminium ion initiated cascade [1,5]-hydrogen transfer/cyclization

Abstract

Incredibly electrophilic keteniminium ions generated in situ were employed as powerful intermediates for cascade [1,5]-hydride transfer/cyclization, via which inert benzylic and non-benzylic C(sp3)–H bonds without a directing group were directly functionalized to furnish complex polycycles in a single operation.

Graphical abstract: Direct functionalization of benzylic and non-benzylic C(sp3)–H bonds via keteniminium ion initiated cascade [1,5]-hydrogen transfer/cyclization

Article information

Article type
Highlight
Submitted
27 Mac 2018
Accepted
27 Apr 2018
First published
28 Apr 2018

Org. Chem. Front., 2018,5, 1854-1858

Direct functionalization of benzylic and non-benzylic C(sp3)–H bonds via keteniminium ion initiated cascade [1,5]-hydrogen transfer/cyclization

L. Xu, P. Yang and L. Wang, Org. Chem. Front., 2018, 5, 1854 DOI: 10.1039/C8QO00314A

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