Issue 31, 2018

Amphiphilic complexes of Ho(iii), Dy(iii), Tb(iii) and Eu(iii) for optical and high field magnetic resonance imaging

Abstract

Lanthanides, holmium(III), dysprosium(III), and terbium(III), were coordinated to an amphiphilic DOTA bis-coumarin derivative and then further assembled with an amphiphilic europium(III) DTPA bis-coumarin derivative into mono-disperse micelles. The self-assembled micelles were characterized and assessed for their potential as bimodal contrast agents for high field magnetic resonance and optical imaging applications. All micelles showed a high transverse relaxation (r2) of 46, 34, and 30 s−1 mM−1 at 500 MHz and 37 °C for Dy(III), Ho(III) and Tb(III), respectively, which is a result of the high magnetic moment of these lanthanides and the long rotational correlation time of the micelles. The quantum yield in aqueous solution ranged from 1.8% for Tb/Eu to 1.4% for Dy/Eu and 1.0% for the Ho/Eu micelles. Multi-photon excited emission spectroscopy has shown that due to the two-photon absorption of the coumarin chromophore the characteristic Eu(III) emission could be observed upon excitation at 800 nm, demonstrating the usefulness of the system for in vivo fluorescence imaging applications. To the best of our knowledge, this is the first example reporting the potential of a holmium(III) chelate as a negative MRI contrast agent.

Graphical abstract: Amphiphilic complexes of Ho(iii), Dy(iii), Tb(iii) and Eu(iii) for optical and high field magnetic resonance imaging

Supplementary files

Article information

Article type
Paper
Submitted
29 Mac 2018
Accepted
09 Mei 2018
First published
11 Mei 2018

Dalton Trans., 2018,47, 10646-10653

Amphiphilic complexes of Ho(III), Dy(III), Tb(III) and Eu(III) for optical and high field magnetic resonance imaging

M. Harris, C. Henoumont, W. Peeters, S. Toyouchi, L. Vander Elst and T. N. Parac-Vogt, Dalton Trans., 2018, 47, 10646 DOI: 10.1039/C8DT01227J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements