Issue 18, 2017

Ratiometric fluorescence monitoring of cerebral Cu2+ based on coumarin-labeled DNA coupled with the Cu2+-induced oxidation of o-phenylenediamine

Abstract

A novel and facile ratiometric fluorescence method for evaluating Cu2+ has been developed based on coumarin-labeled single-stranded DNA (C-ssDNA) coupled with the Cu2+-induced oxidation of o-phenylenediamine (OPD). By combining the microdialysis technique, the ratiometric fluorescence method has also been successfully exploited to monitor the cerebral Cu2+ in the rat brain, promising new opportunities for studying the cerebral Cu2+-associated physiological and pathological events.

Graphical abstract: Ratiometric fluorescence monitoring of cerebral Cu2+ based on coumarin-labeled DNA coupled with the Cu2+-induced oxidation of o-phenylenediamine

Supplementary files

Article information

Article type
Communication
Submitted
01 Jul 2017
Accepted
02 Ago 2017
First published
04 Ago 2017

Analyst, 2017,142, 3341-3345

Ratiometric fluorescence monitoring of cerebral Cu2+ based on coumarin-labeled DNA coupled with the Cu2+-induced oxidation of o-phenylenediamine

S. Ma, Q. Zhou, F. Mu, Z. Chen, X. Ding, M. Zhang and G. Shi, Analyst, 2017, 142, 3341 DOI: 10.1039/C7AN01099K

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