Issue 7, 2016

Development of deep subsurface Raman spectroscopy for medical diagnosis and disease monitoring

Abstract

The recently developed array of Raman spectroscopy techniques for deep subsurface analysis of biological tissues unlocks new prospects for medical diagnosis and monitoring of various biological conditions. The central pillars of these methods comprise spatially offset Raman spectroscopy (SORS) and Transmission Raman Spectroscopy facilitating penetration depths into tissue up to two orders of magnitude greater than those achievable with conventional Raman spectroscopy. This article reviews these concepts and discusses their emerging medical applications including non-invasive breast cancer diagnosis, cancer margin evaluation, bone disorder detection and glucose level determination.

Graphical abstract: Development of deep subsurface Raman spectroscopy for medical diagnosis and disease monitoring

Article information

Article type
Tutorial Review
Submitted
15 Jun 2015
First published
12 Okt 2015
This article is Open Access
Creative Commons BY license

Chem. Soc. Rev., 2016,45, 1794-1802

Author version available

Development of deep subsurface Raman spectroscopy for medical diagnosis and disease monitoring

P. Matousek and N. Stone, Chem. Soc. Rev., 2016, 45, 1794 DOI: 10.1039/C5CS00466G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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