Issue 30, 2016
From the journal:

Chemical Communications

Self-assembly of a 5-fluorouracil-dipeptide hydrogel†

Yuan Sun, ORCID logo a   Jonah A. Kaplan,b   Aileen Shieh,a   Hui-Lung Sun,c   Carlo M. Croce,c   Mark W. Grinstaff*b  and  Jon R. Parquette*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Ave., Columbus, Ohio 43210, USA
E-mail: parquett@chemistry.ohio-state.edu
Fax: +1 614 292-1685

b Departments of Biomedical Engineering and Chemistry, Boston University, 590 Commonwealth Ave., Boston, MA 02215, USA
E-mail: mgrin@bu.edu

c Department of Molecular Virology Immunology and Medical Genetics, The Ohio State University, 460 W. 12th Ave., Columbus, OH 43210, USA

Abstract

The self-assembly of 5-fluorouracil dilysine conjugates into self-supporting hydrogels, comprised of entangled nanofibers or rigid nanotubes with diameters of 10 and 16 nm, respectively, is reported. The rate of release of 5-Fu from the conjugates was highly dependent on concentration in solution, whereas, release from the fully formed hydrogels was significantly slower. The 5-Fu conjugate also exhibited promising in vitro cytotoxicity against human tumor cell lines A549, H460 and H23.

Graphical abstract: Self-assembly of a 5-fluorouracil-dipeptide hydrogel

  • This article is part of the themed collection: Foldamers
About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6CC01195K
Article type
Communication
Submitted
05 Feb 2016
Accepted
04 Mac 2016
First published
09 Mac 2016

Chem. Commun., 2016,52, 5254-5257

Permissions

Request permissions

Self-assembly of a 5-fluorouracil-dipeptide hydrogel

Y. Sun, J. A. Kaplan, A. Shieh, H. Sun, C. M. Croce, M. W. Grinstaff and J. R. Parquette, Chem. Commun., 2016, 52, 5254 DOI: 10.1039/C6CC01195K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements