Issue 40, 2014

Targeting cancer cells with folic acid–iminoboronate fluorescent conjugates

Abstract

Herein we present the synthesis of fluorescent 2-acetylbenzeneboronic acids that undergo B–N promoted conjugation with lysozyme and N-(2-aminoethyl) folic acid (EDA-FA), generating conjugates that are selectively recognized and internalized by cancer cells that over-express folic acid receptors.

Graphical abstract: Targeting cancer cells with folic acid–iminoboronate fluorescent conjugates

Supplementary files

Article information

Article type
Communication
Submitted
01 Okt 2013
Accepted
04 Nov 2013
First published
05 Nov 2013
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 5261-5263

Targeting cancer cells with folic acid–iminoboronate fluorescent conjugates

P. M. S. D. Cal, R. F. M. Frade, V. Chudasama, C. Cordeiro, S. Caddick and P. M. P. Gois, Chem. Commun., 2014, 50, 5261 DOI: 10.1039/C3CC47534D

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