Issue 34, 2013

Complete shift of ferritin oligomerization toward nanocageassemblyvia engineered protein–protein interactions

Abstract

Computational redesign of a dimorphic protein nano-cage at the C3-symmetrical interfaces forces it to assemble into the monomorphic cage. These monodisperse assemblies are at least 20 °C more stable than the parent. This approach adds to the toolkit of bottom-up molecular design with applications in protein engineering and hybrid nano-materials.

Graphical abstract: Complete shift of ferritin oligomerization toward nanocage assembly via engineered protein–protein interactions

Supplementary files

Article information

Article type
Communication
Submitted
01 Feb 2013
Accepted
11 Mac 2013
First published
12 Mac 2013

Chem. Commun., 2013,49, 3528-3530

Complete shift of ferritin oligomerization toward nanocage assembly via engineered proteinprotein interactions

M. S. Ardejani, X. L. Chok, C. J. Foo and B. P. Orner, Chem. Commun., 2013, 49, 3528 DOI: 10.1039/C3CC40886H

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