Issue 6, 2012
From the journal:

Organic & Biomolecular Chemistry

Direct amination of α-substituted nitroacetates using di-tert-butyl azodicarboxylate catalyzed by Hatakeyama's catalyst β-ICD†‡

Cong-Bin Ji,a   Yun-Lin Liu,a   Xiao-Li Zhao,a   Yin-Long Guo,*b   Hao-Yang Wangb  and  Jian Zhou*a  

* Corresponding authors

a Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200062, P. R. China
E-mail: jzhou@chem.ecnu.edu.cn
Fax: +86-21-62234560
Tel: +86-21-62234560

b Shanghai Mass Spectrometry Center, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China
E-mail: ylguo@mail.sioc.ac.cn
Fax: +86-21-54925300

Abstract

We report the first example of catalytic asymmetric direct amination of α-monosubstituted nitroacetates using di-tert-butyl azodicarboxylate. The simple and easily available Hatakeyama's catalyst β-ICD 11 was found to be a highly enantioselective catalyst for this reaction.

Graphical abstract: Direct amination of α-substituted nitroacetates using di-tert-butyl azodicarboxylate catalyzed by Hatakeyama's catalyst β-ICD

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Article information

DOI
https://doi.org/10.1039/C2OB06746C
Article type
Communication
Submitted
18 Okt 2011
Accepted
13 Des 2011
First published
13 Des 2011

Org. Biomol. Chem., 2012,10, 1158-1161

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Direct amination of α-substituted nitroacetates using di-tert-butyl azodicarboxylate catalyzed by Hatakeyama's catalyst β-ICD

C. Ji, Y. Liu, X. Zhao, Y. Guo, H. Wang and J. Zhou, Org. Biomol. Chem., 2012, 10, 1158 DOI: 10.1039/C2OB06746C

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