Issue 38, 2009
From the journal:

Chemical Communications

Palladium-catalysed arylative cyclisation of N-allylacetamides with aryl halides yielding benzyl-substituted oxazolines†‡

Daishi Fujino,a   Sayuri Hayashi,a   Hideki Yorimitsu*a  and  Koichiro Oshima*a  

* Corresponding authors

a Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto-daigaku Katsura, Nishikyo-ku, Kyoto 615-8510, Japan
E-mail: yori@orgrxn.mbox.media.kyoto-u.ac.jp; oshima@orgrxn.mbox.media.kyoto-u.ac.jp
Fax: +81-75-383-2438
Tel: +81-75-383-2437

Abstract

Treatment of N-allylacetamide with aryl halide in the presence of sodium t-butoxide and a palladium catalyst leads to arylative cyclisation to provide the corresponding benzyl-substituted oxazoline in high yield.

Graphical abstract: Palladium-catalysed arylative cyclisation of N-allylacetamides with aryl halides yielding benzyl-substituted oxazolines

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Article information

DOI
https://doi.org/10.1039/B912895F
Article type
Communication
Submitted
30 Jun 2009
Accepted
21 Ago 2009
First published
03 Sep 2009

Chem. Commun., 2009, 5754-5756

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Palladium-catalysed arylative cyclisation of N-allylacetamides with aryl halides yielding benzyl-substituted oxazolines

D. Fujino, S. Hayashi, H. Yorimitsu and K. Oshima, Chem. Commun., 2009, 5754 DOI: 10.1039/B912895F

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