Issue 18, 2023

Hydrogen atoms in supramolecular chemistry: a structural perspective. Where are they, and why does it matter?

Abstract

Hydrogen bonding interactions are ubiquitous across the biochemical and chemical sciences, and are of particular interest to supramolecular chemists. They have been used to assemble hydrogen bonded polymers, cages and frameworks, and are the functional motif in many host–guest systems. Single crystal X-ray diffraction studies are often used as a key support for proposed structures, although this presents challenges as hydrogen atoms interact only weakly with X-rays. In this Tutorial Review, we discuss the information that can be gleaned about hydrogen bonding interactions through crystallographic experiments, key limitations of the data, and emerging techniques to overcome these limitations.

Graphical abstract: Hydrogen atoms in supramolecular chemistry: a structural perspective. Where are they, and why does it matter?

Supplementary files

Article information

Article type
Tutorial Review
Submitted
04 Jul 2023
First published
21 Ago 2023

Chem. Soc. Rev., 2023,52, 6254-6269

Hydrogen atoms in supramolecular chemistry: a structural perspective. Where are they, and why does it matter?

A. L. Thompson and N. G. White, Chem. Soc. Rev., 2023, 52, 6254 DOI: 10.1039/D3CS00516J

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