Issue 11, 2022
From the journal:

Green Chemistry

Deep eutectic solvents meet safe, scalable and sustainable hydrogenations enabled by aluminum powder and Pd/C†

Francesco Messa, ORCID logo a   Giuseppe Dilauro, ORCID logo ab   Andrea Nicola Paparella, ORCID logo a   Lavinia Silvestri,c   Guido Furlotti,c   Tommaso Iacoangeli,c   Serena Perrone ORCID logo *a  and  Antonio Salomone ORCID logo *d  

* Corresponding authors

a Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università del Salento, Prov.le Lecce-Monteroni, I-73100 Lecce, Italy
E-mail: serena.perrone@unisalento.it

b Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro”, Consorzio C.I.N.M.P.I.S., Via E. Orabona 4, I-70125 Bari, Italy

c Angelini Pharma S.p.A., Via Guardapasso, 1, 04011 Aprilia, Italy

d Dipartimento di Chimica, Università degli Studi di Bari “Aldo Moro”, Consorzio C.I.N.M.P.I.S., Via E. Orabona 4, I-70125 Bari, Italy
E-mail: antonio.salomone@uniba.it

Abstract

A general, safe and scalable reductive protocol, based on the in situ generation of H2 from aluminum and water, has been developed in deep eutectic solvents for the reduction of many organic compounds under Pd-catalysis. The methodology has been efficiently applied to the multigram-scale synthesis of benzindopyrine as an active pharmaceutical ingredient.

Graphical abstract: Deep eutectic solvents meet safe, scalable and sustainable hydrogenations enabled by aluminum powder and Pd/C

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Article information

DOI
https://doi.org/10.1039/D2GC00636G
Article type
Communication
Submitted
16 Feb 2022
Accepted
28 Apr 2022
First published
03 Mei 2022

Green Chem., 2022,24, 4388-4394

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Deep eutectic solvents meet safe, scalable and sustainable hydrogenations enabled by aluminum powder and Pd/C

F. Messa, G. Dilauro, A. N. Paparella, L. Silvestri, G. Furlotti, T. Iacoangeli, S. Perrone and A. Salomone, Green Chem., 2022, 24, 4388 DOI: 10.1039/D2GC00636G

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