Issue 28, 2022

The crucial and multifaceted roles of main-group cations and their salts in iron-mediated cross-couplings

Abstract

While a broad variety of iron-catalyzed cross-couplings involve the use of main-group organometallics R–[M] as nucleophiles, the role of the [M]n+ cation in the coupling process is generally disregarded. However, several beneficial effects of [M]n+ cations by themselves or involved in ionic salts used as additives have been observed in such procedures. At the molecular level, interaction of those [M]n+ cations with on-cycle organoiron intermediates can proceed in several ways. Intermolecular interactions can be observed, and also the implication of [M]n+ in the iron's first or second coordination sphere, e.g. by ambiphilic coordination of a [M]–X salt to an R–[Fe] bond. The use of [M]n+ cations in the reaction medium is also a powerful strategy enabling control of the distribution of iron oxidation states within the coupling process.

Graphical abstract: The crucial and multifaceted roles of main-group cations and their salts in iron-mediated cross-couplings

Article information

Article type
Frontier
Submitted
21 Mac 2022
Accepted
28 Apr 2022
First published
04 Mei 2022

Dalton Trans., 2022,51, 10674-10680

The crucial and multifaceted roles of main-group cations and their salts in iron-mediated cross-couplings

V. Wowk and G. Lefèvre, Dalton Trans., 2022, 51, 10674 DOI: 10.1039/D2DT00871H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements