Issue 2, 2019

Biosynthesis of lagopodins in mushroom involves a complex network of oxidation reactions

Abstract

Use of the ku70-deficient strain of Coprinopsis cinerea enabled confirmation within the native context of the central role the sesquiterpene synthase Cop6 plays in lagopodin biosynthesis. Furthermore, yeast in vivo bioconversion and in vitro assays of two cytochrome P450 monooxygenases Cox1 and Cox2 allowed elucidation of the network of oxidation steps that build structural complexity onto the α-cuprenene framework during the biosynthesis of lagopodins. Three new compounds were identified as intermediates formed by the redox enzymes.

Graphical abstract: Biosynthesis of lagopodins in mushroom involves a complex network of oxidation reactions

Supplementary files

Article information

Article type
Communication
Submitted
12 Nov 2018
Accepted
10 Des 2018
First published
10 Des 2018

Org. Biomol. Chem., 2019,17, 234-239

Biosynthesis of lagopodins in mushroom involves a complex network of oxidation reactions

T. Masuya, Y. Tsunematsu, Y. Hirayama, M. Sato, H. Noguchi, T. Nakazawa and K. Watanabe, Org. Biomol. Chem., 2019, 17, 234 DOI: 10.1039/C8OB02814A

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