Issue 5, 2019

Detection of sulfadimethoxine using optical images of liquid crystals

Abstract

A label-free method for sulfadimethoxine (SDM) detection using an aptamer-based liquid crystal biosensor is developed. The sensor probe is fabricated by immobilizing amine-functionalized aptamers onto the glass slide decorating mixed self-assembled layers of triethoxysilylbutyraldehyde (TEA) and N,N-dimethyl-n-octadecyl-3-aminopropyltrimethoxysilylchloride (DMOAP). Liquid crystals (LCs) are supported on the surface and serve as response elements, which assume the homeotropic alignment and cause a dark optical appearance under crossed polarizers. In the presence of SDM, the formation of SDM–aptamer compounds induces a notable change in the topographical structure of the surface, which disturbs the original homeotropic orientation of LCs and results in a bright optical appearance. A detection limit of 10 μg L−1 is obtained, which is far lower than the maximum residue limit (100 μg L−1 in China). This facile method shows good specificity for SDM detection and may have great potential for detecting other small molecules.

Graphical abstract: Detection of sulfadimethoxine using optical images of liquid crystals

Supplementary files

Article information

Article type
Paper
Submitted
25 Okt 2018
Accepted
28 Des 2018
First published
03 Jan 2019

Analyst, 2019,144, 1761-1767

Detection of sulfadimethoxine using optical images of liquid crystals

J. Du, Q. Jiang, X. Lu, L. Chen, Y. Zhang and X. Xiong, Analyst, 2019, 144, 1761 DOI: 10.1039/C8AN02049C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements