Issue 6, 2018

Approach to pactamycin analogues using rhodium(ii)-catalyzed alkene aziridination and C(sp3)–H amination reactions

Abstract

Dirhodium(II)-catalyzed nitrene transfers have been used to prepare a novel synthetic platform bearing the triamino moiety present in pactamycin, jogyamycin and cranomycin. Catalytic intramolecular C(sp3)–H amination and alkene aziridination reactions, the latter followed by a nucleophilic aziridine ring opening, are the key steps of this strategy.

Graphical abstract: Approach to pactamycin analogues using rhodium(ii)-catalyzed alkene aziridination and C(sp3)–H amination reactions

Supplementary files

Article information

Article type
Research Article
Submitted
27 Sep 2017
Accepted
14 Des 2017
First published
21 Des 2017

Org. Chem. Front., 2018,5, 948-953

Approach to pactamycin analogues using rhodium(II)-catalyzed alkene aziridination and C(sp3)–H amination reactions

R. Rodrigues, Y. Lazib, J. Maury, L. Neuville, D. Leboeuf, P. Dauban and B. Darses, Org. Chem. Front., 2018, 5, 948 DOI: 10.1039/C7QO00878C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements