Issue 45, 2018

Catalytic carbene/alkyne metathesis (CAM): a versatile strategy for alkyne bifunctionalization

Abstract

Metal carbene, as a reactive intermediate, has shown versatile applications in modern organic synthesis. One of the priorities in this area is exploration of stable carbene precursors with structural diversity. Catalytic carbene/alkyne metathesis (CAM) with readily available and stable materials, such as α-carbonyl diazo compounds, provides an effective approach for the in situ generation of vinyl carbene intermediates, which is difficult to directly access with other carbene precursors. Thus, novel cascade transformations involving the CAM process for the straightforward construction of polycyclic frameworks have been well documented. Challenges including side reaction control and asymmetric catalysis in this area need to be explored. This review will summarize the recent advances in this field and be divided by the type of the terminating carbene reactions.

Graphical abstract: Catalytic carbene/alkyne metathesis (CAM): a versatile strategy for alkyne bifunctionalization

Article information

Article type
Review Article
Submitted
28 Sep 2018
Accepted
25 Okt 2018
First published
26 Okt 2018

Org. Biomol. Chem., 2018,16, 8677-8685

Catalytic carbene/alkyne metathesis (CAM): a versatile strategy for alkyne bifunctionalization

C. Pei, C. Zhang, Y. Qian and X. Xu, Org. Biomol. Chem., 2018, 16, 8677 DOI: 10.1039/C8OB02420K

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