Issue 32, 2018

Noninvasive real-time monitoring of local drug release using nano-Au-absorbed self-decomposable SiO2 carriers

Abstract

Real time monitoring of drug release at specific local sites by a non-invasive imaging method is critical in patient-specific drug administration in order to avoid insufficient or excess drug dosing. In the present work, we designed a specific carrier system for such a purpose using self-decomposable SiO2 nanoparticles (NPs) with the drug being loaded in the center and Au NPs on the SiO2 NPs as the imaging agent. We discovered a correlation between the drug release from the carrier and the morphological evolution of Au NPs, which also left the carrier and changed their aggregation states along with the drug release process. This finding enabled the real time monitoring of the drug release at local sites (e.g. tumor) in a quantitative manner by recording the CT signal evolution of the Au NPs, as demonstrated in vivo using mice bearing Colo-205 xenografts. The present work provided a promising platform for non-invasive real time tracking on the localized drug release, enabling a variety of personalized therapeutic applications.

Graphical abstract: Noninvasive real-time monitoring of local drug release using nano-Au-absorbed self-decomposable SiO2 carriers

Supplementary files

Article information

Article type
Paper
Submitted
10 Mei 2018
Accepted
11 Jul 2018
First published
12 Jul 2018

Nanoscale, 2018,10, 15332-15338

Noninvasive real-time monitoring of local drug release using nano-Au-absorbed self-decomposable SiO2 carriers

L. Fan, J. Yang, K. C. Leung, C. Song and Q. Li, Nanoscale, 2018, 10, 15332 DOI: 10.1039/C8NR03782E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements