Issue 21, 2017

Unzipping and shearing DNA with electrophoresed nanoparticles in hydrogels

Abstract

We show electric control of unzipping and shearing dehybridization of a DNA duplex anchored to a hydrogel. Tensile force is applied by electrophoresing (25 V cm−1) gold nanoparticles pulling the DNA duplex. The pulled DNA strand is gradually released from the hydrogel. The unzipping release rate is faster than shearing; for example, 3-fold for a 15 base pair duplex, which helps to design electrically driven DNA devices.

Graphical abstract: Unzipping and shearing DNA with electrophoresed nanoparticles in hydrogels

Supplementary files

Article information

Article type
Communication
Submitted
06 Apr 2017
Accepted
02 Mei 2017
First published
05 Mei 2017

Phys. Chem. Chem. Phys., 2017,19, 13414-13418

Unzipping and shearing DNA with electrophoresed nanoparticles in hydrogels

K. Cervantes-Salguero, I. Kawamata, S. M. Nomura and S. Murata, Phys. Chem. Chem. Phys., 2017, 19, 13414 DOI: 10.1039/C7CP02214J

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