Issue 30, 2016

Self-assembly of a 5-fluorouracil-dipeptide hydrogel

Abstract

The self-assembly of 5-fluorouracil dilysine conjugates into self-supporting hydrogels, comprised of entangled nanofibers or rigid nanotubes with diameters of 10 and 16 nm, respectively, is reported. The rate of release of 5-Fu from the conjugates was highly dependent on concentration in solution, whereas, release from the fully formed hydrogels was significantly slower. The 5-Fu conjugate also exhibited promising in vitro cytotoxicity against human tumor cell lines A549, H460 and H23.

Graphical abstract: Self-assembly of a 5-fluorouracil-dipeptide hydrogel

  • This article is part of the themed collection: Foldamers

Supplementary files

Article information

Article type
Communication
Submitted
05 Feb 2016
Accepted
04 Mac 2016
First published
09 Mac 2016

Chem. Commun., 2016,52, 5254-5257

Self-assembly of a 5-fluorouracil-dipeptide hydrogel

Y. Sun, J. A. Kaplan, A. Shieh, H. Sun, C. M. Croce, M. W. Grinstaff and J. R. Parquette, Chem. Commun., 2016, 52, 5254 DOI: 10.1039/C6CC01195K

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