Issue 46, 2015

Base promoted direct C4-arylation of 4-substituted-pyrazolin-5-ones with diaryliodonium salts

Abstract

A metal-free approach for the C4-arylation of 4-substituted-pyrazolin-5-ones with diaryliodonium salts was developed. The reaction proceeded smoothly at room temperature in the presence of DMAP (4-dimethylaminopyridine). As a result, a wide range of desired multi-substituted pyrazolin-5-one derivatives were obtained in good to excellent yields (20–98%).

Graphical abstract: Base promoted direct C4-arylation of 4-substituted-pyrazolin-5-ones with diaryliodonium salts

Supplementary files

Article information

Article type
Communication
Submitted
04 Mac 2015
Accepted
17 Apr 2015
First published
17 Apr 2015

RSC Adv., 2015,5, 36390-36393

Base promoted direct C4-arylation of 4-substituted-pyrazolin-5-ones with diaryliodonium salts

S. Mao, X. Geng, Y. Yang, X. Qian, S. Wu, J. Han and L. Wang, RSC Adv., 2015, 5, 36390 DOI: 10.1039/C5RA03819G

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