Issue 16, 2013

β-Cyclodextrin-crosslinked alginate gel for patient-controlled drug delivery systems: regulation of host–guest interactions with mechanical stimuli

Abstract

Macroscopic mechanical force has attracted much attention as an existing yet novel energy source for modification of molecular interactions and molecular reactivity. Although various molecular level phenomena have been controlled by using macroscopic mechanical forces, control of host–guest inclusion has not been a research target. Here we report a novel controlled release system triggered by a mechanical stimulus. Release of ondansetron (ODN), an anti-emetic drug, from a designer hydrogel composed of a β-cyclodextrin (CyD) derivative and alginate (AL) can be controlled by mild mechanical compressions that mimic operation by a patient's hand. ODN is released in response to mechanical compressions by changing the inclusion ability of CyD moieties, which may be conformationally distorted, and/or suppressed stabilization of the inclusion complex when an external stress is applied. It is revealed that the release can be induced even by the slight conformational restriction for β-CyD due to the mechanical stimulus. This controlled release technology provides a novel dosing strategy enabling on-demand administration of medicines through a mechanical stimulus generated intentionally by the patient.

Graphical abstract: β-Cyclodextrin-crosslinked alginate gel for patient-controlled drug delivery systems: regulation of host–guest interactions with mechanical stimuli

Supplementary files

Article information

Article type
Paper
Submitted
07 Des 2012
Accepted
13 Feb 2013
First published
14 Feb 2013

J. Mater. Chem. B, 2013,1, 2155-2161

β-Cyclodextrin-crosslinked alginate gel for patient-controlled drug delivery systems: regulation of host–guest interactions with mechanical stimuli

H. Izawa, K. Kawakami, M. Sumita, Y. Tateyama, J. P. Hill and K. Ariga, J. Mater. Chem. B, 2013, 1, 2155 DOI: 10.1039/C3TB00503H

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