Issue 19, 2012
From the journal:

Organic & Biomolecular Chemistry

A highly enantioselective approach towards 2-substituted 3-bromopyrrolidines†‡

Jie Chen,a   Ling Zhoua  and  Ying-Yeung Yeung*a  

* Corresponding authors

a Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543
E-mail: chmyyy@nus.edu.sg
Fax: +65 6779 1691
Tel: +65 6516 7760

Abstract

A facile and highly enantioselective approach towards 2-substituted 3-bromopyrrolidines has been developed. The process involves an amino-thiocarbamate catalyzed bromoaminocyclization of 1,2-disubstituted olefinic amides. The pyrrolidine products could readily be converted into other useful building blocks including a dihydropyrrole and a 2-substituted pyrrolidine.

Graphical abstract: A highly enantioselective approach towards 2-substituted 3-bromopyrrolidines

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2OB25327E
Article type
Communication
Submitted
14 Feb 2012
Accepted
06 Mac 2012
First published
07 Mac 2012

Org. Biomol. Chem., 2012,10, 3808-3811

Permissions

Request permissions

A highly enantioselective approach towards 2-substituted 3-bromopyrrolidines

J. Chen, L. Zhou and Y. Yeung, Org. Biomol. Chem., 2012, 10, 3808 DOI: 10.1039/C2OB25327E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements