Themed collection Biomedical Polymer Materials

31 items
Editorial

Introduction to “Biomedical Polymer Materials”

Xuesi Chen and Huayu Tian introduce the Biomaterials Science and Journal of Materials Chemistry B cross-journal themed collection on Biomedical Polymer Materials.

Graphical abstract: Introduction to “Biomedical Polymer Materials”
From the themed collection: Biomedical Polymer Materials
Highlight

Polyprodrugs for tumor chemotherapy: from molecular structure to drug release performance

The structure–property relationship of polyprodrugs was explored from the perspective of molecular structure, by discussing the effects of the conjugations and linkers on their drug content and drug releasing performance.

Graphical abstract: Polyprodrugs for tumor chemotherapy: from molecular structure to drug release performance
From the themed collection: Biomedical Polymer Materials
Minireview

Natural products applied in acute kidney injury treatment: polymer matters

The applications of renal-targeting natural polymers and polymer-delivered natural drugs for the treatment of lethal acute kidney injury are summarized.

Graphical abstract: Natural products applied in acute kidney injury treatment: polymer matters
From the themed collection: Biomedical Polymer Materials
Review Article

Application of biomaterials in the treatment of intracerebral hemorrhage

In this review, the application of nanomaterials and hydrogels in the treatment of intracerebral hemorrhage is summarized. In addition, the potential challenges and prospects of these biomaterials for clinical translation are discussed.

Graphical abstract: Application of biomaterials in the treatment of intracerebral hemorrhage
From the themed collection: Biomedical Polymer Materials
Review Article

Recent progress in nanomaterials for bacteria-related tumor therapy

Recent progress in nanomaterials for bacteria-related tumor therapy in terms of chemotherapy, immunotherapy and synergistic therapy is summarized in this review in order to provide some insights into this emerging and rapidly growing research area.

Graphical abstract: Recent progress in nanomaterials for bacteria-related tumor therapy
From the themed collection: Biomedical Polymer Materials
Review Article

Blood–brain barrier-crossing dendrimers for glioma theranostics

Blood–brain barrier-crossing dendrimers for glioma imaging diagnostics, chemotherapy, gene therapy, or imaging-guided therapy have been concisely reviewed with perspectives briefly discussed.

Graphical abstract: Blood–brain barrier-crossing dendrimers for glioma theranostics
From the themed collection: Biomedical Polymer Materials
Review Article

Renal-clearable nanoprobes for optical imaging and early diagnosis of diseases

We summarize the advancements of renal-clearable organic nanoprobes for optical imaging and remote urinalysis. The versatile design strategies are discussed along with their challenges and perspectives for the development of next-generation renal-clearable nanoprobes.

Graphical abstract: Renal-clearable nanoprobes for optical imaging and early diagnosis of diseases
From the themed collection: Biomedical Polymer Materials
Review Article

Organic–inorganic composite hydrogels: compositions, properties, and applications in regenerative medicine

Organic–inorganic composite hydrogels, with its polymeric networks interacting with inorganic fillers via different modes, provide a versatile platform for regenerative medicine.

Graphical abstract: Organic–inorganic composite hydrogels: compositions, properties, and applications in regenerative medicine
From the themed collection: Biomedical Polymer Materials
Review Article

Hydroxyl-rich branched polycations for nucleic acid delivery

Amine-epoxide ring-opening polymerization was carried out to construct a hydroxyl-rich branched polycation and based on a one-pot strategy for the flexible introduction and multifunctional modification of responsive molecules.

Graphical abstract: Hydroxyl-rich branched polycations for nucleic acid delivery
From the themed collection: Biomedical Polymer Materials
Paper

Thiol-containing hyperbranched polysiloxane for scavenging reactive oxygen species

Thiol-containing hyperbranched polysiloxane, a unconventional luminescent polymer, for scavenging intracellular reactive oxygen species.

Graphical abstract: Thiol-containing hyperbranched polysiloxane for scavenging reactive oxygen species
From the themed collection: Journal of Materials Chemistry B HOT Papers
Paper

Preparation of viromimetic rod-like nanoparticle vaccines (RLNVax) and study of their humoral immune activation efficacy

Antigen proteins were modified onto the surfaces of nanoparticles with various shapes. This study investigates the effect of structural anisotropy on the efficacy of humoral immune activation by nanoparticle vaccines.

Graphical abstract: Preparation of viromimetic rod-like nanoparticle vaccines (RLNVax) and study of their humoral immune activation efficacy
From the themed collection: Biomedical Polymer Materials
Paper

ROS-responsive thermosensitive polypeptide hydrogels for localized drug delivery and improved tumor chemoimmunotherapy

A ROS-responsive hydrogel was developed as a platform for co-delivery of a chemotherapeutic drug (DOX), an immunological adjuvant (R848) and an ICB antibody (aPD-1) for combination tumor therapy and prevention of post-operative tumor recurrence.

Graphical abstract: ROS-responsive thermosensitive polypeptide hydrogels for localized drug delivery and improved tumor chemoimmunotherapy
From the themed collection: Biomedical Polymer Materials
Open Access Paper

Developing an in vitro model of haematoma for study of intracerebral haemorrhage

Intracerebral haemorrhage (ICH) is a devastating neurovascular attack with limited treatment options.

Graphical abstract: Developing an in vitro model of haematoma for study of intracerebral haemorrhage
From the themed collection: Biomedical Polymer Materials
Open Access Paper

The effect of charge and albumin on cellular uptake of supramolecular polymer nanostructures

Bovine serum albumin (BSA) regulates cellular internalization of charged ureido-pyrimidinone (UPy)-assembly. The BSA-bond UPy-assembly can be internalized and co-localizes with mitochondria. Without BSA, the UPy-assembly anchors to the cell membrane.

Graphical abstract: The effect of charge and albumin on cellular uptake of supramolecular polymer nanostructures
From the themed collection: Biomedical Polymer Materials
Paper

A mitochondria-targeting heptamethine cyanine-chlorambucil formulated polymeric nanoparticle to potentiate native tumor chemotherapeutic efficacy

Facile conjugation of chlorambucil with IR775 chloride can afford IR775-Cbl with mitochondria-targeting potency for tumor cells, exhibiting distinct “1 + 1 > 2” tumor inhibition.

Graphical abstract: A mitochondria-targeting heptamethine cyanine-chlorambucil formulated polymeric nanoparticle to potentiate native tumor chemotherapeutic efficacy
From the themed collection: Biomedical Polymer Materials
Paper

Enhancing the tumor penetration of multiarm polymers by collagenase modification

Col modification significantly enhanced the tumor penetration and therapy efficacy of multiarm polymer-based nanomedicines.

Graphical abstract: Enhancing the tumor penetration of multiarm polymers by collagenase modification
From the themed collection: Biomedical Polymer Materials
Paper

Optimization of lipid assisted polymeric nanoparticles for siRNA delivery and cancer immunotherapy

A siRNA delivery system was developed using clinically approved mPEG-b-PLGA, cationic lipid and ionizable lipid for siRNA delivery and cancer immunotherapy.

Graphical abstract: Optimization of lipid assisted polymeric nanoparticles for siRNA delivery and cancer immunotherapy
From the themed collection: Biomedical Polymer Materials
Paper

A highly tuneable inverse emulsion polymerization for the synthesis of stimuli-responsive nanoparticles for biomedical applications

This article demonstrates an inverse emulsion scheme to polymerize a variety of ionizable and non-ionizable monomers to form stimuli-responsive nanoparticles with potential applications in biomaterials science.

Graphical abstract: A highly tuneable inverse emulsion polymerization for the synthesis of stimuli-responsive nanoparticles for biomedical applications
From the themed collection: Biomedical Polymer Materials
Open Access Paper

Preparation of glycopeptide-modified pH-sensitive liposomes for promoting antigen cross-presentation and induction of antigen-specific cellular immunity

Soybean agglutinin-derived glycopeptide-introduced pH-responsive polysaccharide-modified liposomes promote the cross-presentation and induction of antigen-specific cellular immune responses.

Graphical abstract: Preparation of glycopeptide-modified pH-sensitive liposomes for promoting antigen cross-presentation and induction of antigen-specific cellular immunity
From the themed collection: Biomedical Polymer Materials
Paper

Nitric oxide-scavenging hyaluronic acid nanoparticles for osteoarthritis treatment

This study presents a novel hyaluronic acid (HA)-based nanoparticles with dual effects for osteoarthritis (OA) treatment, combining anti-inflammatory effects through nitric oxide (NO) scavenging and lubrication effect provided by HA.

Graphical abstract: Nitric oxide-scavenging hyaluronic acid nanoparticles for osteoarthritis treatment
From the themed collection: Biomedical Polymer Materials
Open Access Paper

A quaternary ammonium-based nanosystem enables delivery of CRISPR/Cas9 for cancer therapy

Chol-PEG and Qua-PLL were self-assembled with a Cas9/PLK1 sgRNA ribonucleoprotein to form a ternary nanoparticle QNP/RNPPLK1 for efficient cancer therapy.

Graphical abstract: A quaternary ammonium-based nanosystem enables delivery of CRISPR/Cas9 for cancer therapy
From the themed collection: Biomedical Polymer Materials
Paper

Wound microenvironment regulatory poly(L-glutamic acid) composite hydrogels containing metal ion-coordinated nanoparticles for effective hemostasis and wound healing

A wound microenvironment regulatory poly(L-glutamic acid) composite hydrogel can promote cell proliferation, migration, and angiogenesis, alleviate inflammation and polarize pro-inflammatory M1 macrophages into pro-healing M2 macrophages, thus accelerating wound healing.

Graphical abstract: Wound microenvironment regulatory poly(l-glutamic acid) composite hydrogels containing metal ion-coordinated nanoparticles for effective hemostasis and wound healing
From the themed collection: Biomedical Polymer Materials
Paper

Quaternary ammonium-tethered hyperbranched polyurea nanoassembly synergized with antibiotics for enhanced antimicrobial efficacy

The rifampicin-loaded HPUs-QA nanoassembly (HPUs-Rif/QA) demonstrated a synergistic antimicrobial effect in killing planktonic bacteria and eradicating the corresponding biofilms.

Graphical abstract: Quaternary ammonium-tethered hyperbranched polyurea nanoassembly synergized with antibiotics for enhanced antimicrobial efficacy
From the themed collection: Biomedical Polymer Materials
Paper

Fibrous capsule-resistant, controllably degradable and functionalizable zwitterion-albumin hybrid hydrogels

We present a biocompatible, controllably degradable, and functionalizable zwitterion-albumin hybrid hydrogel with long-term resistance against foreign body responses.

Graphical abstract: Fibrous capsule-resistant, controllably degradable and functionalizable zwitterion-albumin hybrid hydrogels
From the themed collection: Biomedical Polymer Materials
Open Access Paper

Nano-in-nano enteric protein delivery system: coaxial Eudragit® L100-55 fibers containing poly(N-vinylcaprolactam) nanogels

Novel nano-in-nano coaxial platform for enteric protein delivery.

Graphical abstract: Nano-in-nano enteric protein delivery system: coaxial Eudragit® L100-55 fibers containing poly(N-vinylcaprolactam) nanogels
From the themed collection: Biomedical Polymer Materials
Paper

A transdermal drug delivery system based on dissolving microneedles for boron neutron capture therapy of melanoma

A transdermal drug delivery system based on PVA/F-BPA microneedles for BNCT of melanoma.

Graphical abstract: A transdermal drug delivery system based on dissolving microneedles for boron neutron capture therapy of melanoma
From the themed collection: Biomedical Polymer Materials
Paper

Phosphorus core–shell tecto dendrimers for enhanced tumor imaging: the rigidity of the backbone matters

Phosphorus core–shell tecto dendrimers with rigid cores enable enhanced fluorescence/SPECT dual-mode tumor imaging likely through an amplified enhanced permeability and retention effect.

Graphical abstract: Phosphorus core–shell tecto dendrimers for enhanced tumor imaging: the rigidity of the backbone matters
From the themed collection: Biomedical Polymer Materials
Paper

Adhesive and biodegradable polymer mixture composed of high -biosafety pharmaceutical excipients as non-setting periodontal dressing

A soft, non-setting and degradable periodontal dressing with biodegradability was developed using sodium carboxymethyl cellulose, Eudragit S 100 and povidone K30. The periodontal dressings could promote mucosal wound healing.

Graphical abstract: Adhesive and biodegradable polymer mixture composed of high -biosafety pharmaceutical excipients as non-setting periodontal dressing
From the themed collection: Biomedical Polymer Materials
Paper

Surface chemistry mediates the tumor entrance of nanoparticles probed using single-molecule dual-imaging nanodots

We develop single-molecule dual-imaging nanodots by divergent growth for fluorescence and MR imaging of surface chemistry-dependent tumor entrance. The results show that the surface chemistry of nanoparticles can dominate the ways of tumor entrance.

Graphical abstract: Surface chemistry mediates the tumor entrance of nanoparticles probed using single-molecule dual-imaging nanodots
From the themed collection: Biomedical Polymer Materials
Open Access Paper

The role of Eudragit® as a component of hydrogel formulations for medical devices

A systematic analysis is presented, highlighting the unique properties of Eudragits as additive in mucoadhesive hydrogels for ocular protein delivery.

Graphical abstract: The role of Eudragit® as a component of hydrogel formulations for medical devices
From the themed collection: Biomedical Polymer Materials
Paper

Biodegradable covalent organic frameworks achieving tumor micro-environment responsive drug release and antitumor treatment

A biodegradable COF was constructed to break in response to tumors, enhancing the therapeutic effect on tumors.

Graphical abstract: Biodegradable covalent organic frameworks achieving tumor micro-environment responsive drug release and antitumor treatment
From the themed collection: Biomedical Polymer Materials
31 items

About this collection

Biomedical polymer materials, as materials for diagnosis, treatment and organ regeneration, have the mission of prolonging patients' lives and improving their quality of life. Their research occupies a very important position in the fields of biotechnology, life sciences and medicine, and different fields of biomedicine have different requirements for biomedical materials. Thus, in order to promote the development of the medical field, the synthesis of new biomaterials is of great significance. This themed collection across Journal of Materials Chemistry B and Biomaterials Science is Guest Edited by Professors Huayu Tian (0000-0002-2482-3744) and Xuesi Chen (0000-0001-7355-6446) (Changchun Institute of Applied Chemistry, Chinese Academy of Sciences) and features some of the recent articles surrounding the topic of biomedical polymer materials. We hope that this collection will give readers an overview of some of the most recent work concerning the materials chemistry and applications of novel biomedical polymer materials and will help to further exciting research in the field.


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