The new seventeen oxindolylideneimidazothiazolotriazines synthesized by aldol condensation of imidazo[4,5-e]thiazolo[3,2-b]-1,2,4-triazine-2,7-diones with isatins followed by skeletal rearrangement exhibited high antiproliferative activity.
A new [Au(I)] catalyzed intramolecular hydrocarboxylation of allenes is presented as a valuable synthetic route to oxazino-indolones.
Twelve new chiral PCN pincer Pd(II) complexes with varied chiral imidazoline moieties have been synthesized, structurally characterized and used as catalysts for enantioselective hydrophosphination of 2-alkenoylpyridines with diphenylphosphine.
A regioselective para-alkylation of pyridines using alkyl carboxylic acid-derived diacyl peroxides or peresters is reported. This reaction proceeds under mild conditions, and late-stage functionalization of complex pyridines can be realized.
I2/CF3CO2Ag-mediated iodolactonization of allenoic acids has been developed to synthesize various 6- to 9-membered ring vinylic iodolactones in 16–89% yield.