Novel FAK protein inhibitors were developed as potential therapeutic agents via the Monte Carlo method. Detailed computational analyses reveal their binding properties and potential efficacy for drug development.
We designed and synthesized a series of novel diaminopyrimidine compounds as FAK inhibitors. Among them, A12 could be used as a valuable lead compound for the discovery of novel FAK-targeted anticancer drugs.
The critical role and mechanism of the topography of materials to regulate the function and fate of mesenchymal stem cells are reported.
Focal adhesion kinase is upregulated in various types of cancer and has become an important research target for the development of more effective anticancer drugs.
Due to the important role of protein kinases in protein phosphorylation within vital cellular processes, their abnormal function, especially in cancer situations, has underscored their importance in therapy.