Jiaqian Wan, Yu Zou, Ruiqing Sun, Zhengdong Xu, Jiaxing Tang, Yehong Gong, Guanghong Wei and Qingwen Zhang
Phys. Chem. Chem. Phys., 2023,25, 16856-16865
Abstract
The structural stability of AD-tau and CTE-tau and destabilization of CTE-tau protofilament by purpurin molecules.
Pengxuan Xia, Yujie Chen, Jiaxing Tang, Lulu Guan, Dushuo Feng and Yu Zou
Nanoscale, 2026, Advance Article
From themed collection:
Nanoscale 2026 Emerging Investigators
Abstract
Multiscale simulations reveal that the V337M mutation enhances β-structure formation and stabilizes compact PHF6** oligomers, promoting persistent bilayer β-sheet assemblies and accelerating early-stage tau aggregation.
Shubhangini Singh Verma and Nitin Chaudhary
RSC Adv., 2025,15, 22216-22227
Abstract
Ac-PHF6 (CH3CO-VQIVYK-NH2) and its analogs with electron-deficient aromatic rings form hydrogels with comparable rheological properties.
Avneet Kour, Virendra Tiwari, Nidhi Aggarwal, Himanshu Sekhar Panda, Ashwani Kumar, Siddharth Tiwari, Virander Singh Chauhan, Shubha Shukla and Jiban Jyoti Panda
Nanoscale, 2023,15, 12748-12770
From themed collection:
Celebrating International Women’s day 2024: Women in Nanoscience
Abstract
Synthesis of RΔF nanosphere-capped SeNPs with anti-amyloidogenic potency towards peptide aggregates. NPs can cross the BBB, exhibit protective effects against STZ-induced cytotoxicity in neuronal cells, and improve cognitive performance in STZ-induced rat AD models.
Michael Emad, Reham Waheed, Zeinab Mostafa, Sarah S. Darwish, Rosa Purgatorio, Daniela Valeria Miniero, Annalisa De Palma, Tzu-Peng Cheng, Yu-Cheng Chen, Moustafa Gabr, Ahmed M. El Kerdawy, Marco Catto, Ashraf H. Abadi, Tsong-Long Hwang and Mohammad Abdel-Halim
RSC Med. Chem., 2026,17, 630-657
Abstract
A novel series of pyrazolidinones and pyrazolidinediones was developed as selective COX-2 inhibitors, exhibiting anti-amyloid β, anti-tau, and neuroprotective activities.