Two supramolecular barrel-rosette chloride channels are reported using bis(1,3-propanediol)-based molecules. The system with an additional amide tail showed superior transport activity than that with an ester tail due to better self-assembly.
A hitherto unreported catalyst-free ring expansion reaction of tetrahydroisoquinolines with o-alkynylarylaldehydes for the construction of the dibenzo[b,d]azepine skeleton is described.
The enantioselective de novo synthesis of pharmacologically important 14-hydroxy-6-oxomorphinans is described. 4,5-Desoxynaltrexone and 4,5-desoxynaloxone were prepared using this route and their biological activities against the opioid receptors were measured.
Celastraceae sesquiterpene alkaloids display an array of biological properties and comprise oxygenated dihydroagarofuran cores often adorned with pyridyl macrodilactone bridging ligands. Here, the history and syntheses of these ligands are reviewed.
Solvent-free synthesis of β-C-glycosylated methylidene succinimides using the Wittig olefination reaction and subsequent Lewis acid-mediated deprotection has been reported. Docking studies reveal that these compounds are selective and potent inhibitors of the E6 oncoprotein of high-risk type HPV16.