Design, synthesis, and cytotoxic evaluation of quinazoline-based derivatives as VEGER-2 inhibitors: comparative study against EGFR kinase activity, induction of apoptosis, and molecular docking study

Reda R. Mabrouk, Arafa Musa, Maged Mohammed Saleh Al Ward, Shaimaa Hussein, Ahmed K. B. Aljohani, Mohamed Ayman El-Zahabi and Alaa Elwan

RSC Adv., 2025, 15, 29593
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New nicotinamide–thiadiazol hybrids as VEGFR-2 inhibitors for breast cancer therapy: design, synthesis and in silico and in vitro evaluation

Walid E. Elgammal, Hazem Elkady, Reda G. Yousef, Wagdy M. Eldehna, Dalal Z. Husein, Fatma G. Amin, Bshra A. Alsfouk, Eslam B. Elkaeed, Ibrahim H. Eissa and Ahmed M. Metwaly

RSC Adv., 2025, 15, 14477
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Rationale design and synthesis of new apoptotic thiadiazole derivatives targeting VEGFR-2: computational andin vitrostudies

Walid E. Elgammal, Hazem Elkady, Hazem A. Mahdy, Dalal Z. Husein, Aisha A. Alsfouk, Bshra A. Alsfouk, Ibrahim M. Ibrahim, Eslam B. Elkaeed, Ahmed M. Metwaly and Ibrahim H. Eissa

RSC Adv., 2023, 13, 35853
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Evaluation of oxadiazole- N -phenylacetamide conjugates as VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative assessment, molecular docking, and dynamics studies

Islam I. Otify, Rezk R. A. Ayyad, Ismail Celik, Helmy Sakr and Alaa Elwan

Future Medicinal Chemistry, 2026, 18, 19
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Benzimidazole-derived VEGFR-2 inhibitors: Docking, ADMET, anticancer evaluations, design and synthesis

Ibrahim Mohammed Hepishy, Helmy Sakr, Fathalla Khedr, Khaled El‐Adl and Mo’men Salem

Journal of Molecular Structure, 2026, 1360, 145575
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Design and synthesis of thiadiazoles as anticancer, apoptotic, and VEGFR-2 inhibitors

Walid E. Elgammal, Hazem Elkady, Mohammed A. Dahab, Hazem A. Mahdy, Mohamed Hagras, Ahmed Nofal, Bshra A. Alsfouk, Eslam B. Elkaeed, Ibrahim H. Eissa and Ahmed M. Metwaly

Future Medicinal Chemistry, 2025, 17, 915
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Thiadiazole‐Derived VEGFR‐2 Inhibitors: From Design to Anticancer Evaluation

Aisha A. Alsfouk, Eslam B. Elkaeed, Hazem Elkady, Walid E. Elgammal, Hazem A. Mahdy, Ahmed Nofal, Ibrahim H. Eissa, Dalal Z. Husein, Ibrahim M. Ibrahim, Mahmoud S. Elkotamy and Ahmed M. Metwaly

Chem Biol Drug Des, 2026, 107
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Identification, characterization and biological studies of kinesine spindle protein inhibitor, benzo[b][1,4]oxazine-6-carboxamide derivative, via 3D-pharmacophore virtual screening

Samia A. Elseginy

Journal of Molecular Structure, 2024, 1312, 138508
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Computer-assisted drug discovery (CADD) of an anti-cancer derivative of the theobromine alkaloid inhibiting VEGFR-2

Ibrahim H. Eissa, Reda G. Yousef, Mostafa A. Asmaey, Hazem Elkady, Dalal Z. Husein, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Mohamed A. Elkady, Eslam B. Elkaeed and Ahmed M. Metwaly

Saudi Pharmaceutical Journal, 2023, 31, 101852
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From Synthesis to Mechanism: Biological Evaluation of a p-Toluidine-Based Thiazolidinone-Quinoline VEGFR-2 Candidate Supported by CADD

Emad Manni, Modather F. Hussein, Sara Elkady, Adel A.-H. Abdel-Rahman, Mohamed A. Hawata, Wael A. El-Sayed, Ahmed F. El-Sayed and Hagar S. El-Hema

IJMS, 2026, 27, 3018
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New benzimidazole‐oxadiazole derivatives as potent VEGFR‐2 inhibitors: Synthesis, anticancer evaluation, and docking study

Ulviye Acar Çevik, Ismail Celik, Şennur Görgülü, Zeynep Deniz Şahin Inan, Hayrani Eren Bostancı, Yusuf Özkay and Zafer Asım Kaplacıklı

Drug Development Research, 2024, 85
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Design, synthesis, and biological investigations of new pyrazole derivatives as VEGFR2/CDK-2 inhibitors targeting liver cancer

Manar G. Salem, Mohamed S. Nafie, Aya A. Elzamek, Hosam A. Elshihawy, Mamdouh A. Sofan and Elham Negm

BMC Chemistry, 2024, 18
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In Vitro and In Silico Evaluation of the Anticancer and Antiparasitic Activities of New 2‐Methoxy Azachalconium Bromides

Mai F. AlSakhen, Sana I. Kanaan, Khaled Saleh, Salem R. Yasin, Ibrahim S. Al nasr, Waleed S. Koko, Tariq A. Khan, Kamal A. Qureshi, Rainer Schobert, Bernhard Biersack and Lubna Tahtamouni

ChemistrySelect, 2025, 10
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New thiazolidine-2,4-diones as potential anticancer agents and apoptotic inducers targeting VEGFR-2 kinase: Design, synthesis, in silico and in vitro studies

Hazem Elkady, Hazem A. Mahdy, Mohammed S. Taghour, Mohammed A. Dahab, Alaa Elwan, Mohamed Hagras, Mona H. Hussein, Ibrahim M. Ibrahim, Dalal Z. Husein, Eslam B. Elkaeed, Aisha A. Alsfouk, Ahmed M. Metwaly and Ibrahim H. Eissa

Biochimica et Biophysica Acta (BBA) - General Subjects, 2024, 1868, 130599
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The emerging role of Oxadiazole derivatives as VEGFR and EGFR inhibitors in Cancer therapy

Rajarshi Nath, Biplab Debnath, Anhic Chakraborty, Shah Alam Khan, Arindam Maity and Md Jawaid Akhtar

Bioorganic Chemistry, 2025, 166, 109140
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Discovery of New VEGFR-2 Inhibitors and Apoptosis inducer-based thieno[2,3- d ]pyrimidine

Souad A El-Metwally, Hazem Elkady, Mohamed Hagras, Eslam B Elkaeed, Bshra A Alsfouk, Ahmed S Doghish, Ibrahim M Ibrahim, Mohammed S Taghour, Dalal Z Husein, Ahmed M Metwaly and Ibrahim H Eissa

Future Med. Chem., 2023, 15, 2065
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Design, synthesis, in vitro, and in silico studies of new thiadiazol derivatives as promising VEGFR-2 inhibitors and apoptosis inducers

Hazem A. Mahdy, Hazem Elkady, Walid E. Elgammal, Eslam B. Elkaeed, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Dalal Z. Husein, Mohamed A. Elkady, Ahmed M. Metwaly and Ibrahim H. Eissa

Journal of Molecular Structure, 2024, 1316, 139019
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Targeting Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2): Latest Insights on Synthetic Strategies

Carolina S. Marques, Pedro Brandão and Anthony J. Burke

Molecules, 2024, 29, 5341
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Research on university laboratory management and maintenance framework based on computer aided technology

Jiaqing Yao and Zheng Yuan

Applied Mathematics and Nonlinear Sciences, 2025, 10
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Novel N -Arylmethyl-aniline/chalcone hybrids as potential VEGFR inhibitors: synthesis, biological evaluations, and molecular dynamic simulations

Hesham Haffez, Nosaiba A. Elsayed, Marwa F. Ahmed, Samar S. Fatahala, Eman F. Khaleel, Rehab Mustafa Badi, Eslam B. Elkaeed, Mahmoud A. El Hassab, Sherif F. Hammad, Wagdy M. Eldehna, Nicolas Masurier and Radwan El-Haggar

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38
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Discovery of new thiazolidine-2,4-dione derivatives as potential VEGFR-2 inhibitors: In vitro and in silico studies

Ibrahim H. Eissa, Hazem Elkady, Mahmoud Rashed, Alaa Elwan, Mohamed Hagras, Mohammed A. Dahab, Mohammed S. Taghour, Ibrahim M. Ibrahim, Dalal Z. Husein, Eslam B. Elkaeed, Hanan A. Al-ghulikah, Ahmed M. Metwaly and Hazem A. Mahdy

Heliyon, 2024, 10, e24005
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