Portable paper-in-tip spray ionization for the direct mass spectrometric analysis of target analytes in biofluid samples

Fangfang Lu, Yajun Zheng, Yuan Zhang, Qiang Ma and Zhiping Zhang

Anal. Methods, 2022, 14, 222
DOI: 10.1039/D1AY01907D

Touch spray mass spectrometry for in situ analysis of complex samples

Kevin S. Kerian, Alan K. Jarmusch and R. Graham Cooks

Analyst, 2014, 139, 2714
DOI: 10.1039/C4AN00548A

A new insert sample approach to paper spray mass spectrometry: a paper substrate with paraffin barriers

T. C. Colletes, P. T. Garcia, R. B. Campanha, P. V. Abdelnur, W. Romão, W. K. T. Coltro and B. G. Vaz

Analyst, 2016, 141, 1707
DOI: 10.1039/C5AN01954K

Paper spray mass spectrometry utilizing Teslin® substrate for rapid detection of lipid metabolite changes during COVID-19 infection

Imesha W. De Silva, Subhayu Nayek, Vijay Singh, Jay Reddy, John K. Granger and Guido F. Verbeck

Analyst, 2020, 145, 5725
DOI: 10.1039/D0AN01074J

Negative electrospray ionization on porous supporting tips for mass spectrometric analysis: electrostatic charging effect on detection sensitivity and its application to explosive detection

Melody Yee-Man Wong, Sin-Heng Man, Chi-Ming Che, Kai-Chung Lau and Kwan-Ming Ng

Analyst, 2014, 139, 1482
DOI: 10.1039/c3an01657a

Rapid, in situ detection of cocaine residues based on paper spray ionization coupled with ion mobility spectrometry

Ming Li, Jingjing Zhang, Jie Jiang, Jing Zhang, Jing Gao and Xiaolin Qiao

Analyst, 2014, 139, 1687
DOI: 10.1039/c3an02198j

Rapid screening of agrochemicals by paper spray ionization and leaf spray mass spectrometry: which technique is more appropriate?

Igor Pereira, Stéfany R. M. Rodrigues, Thays C. de Carvalho, Verônica V. Carvalho, Germán S. Lobón, João F. P. Bassane, Eloilson Domingos, Wanderson Romão, Rodinei Augusti and Boniek G. Vaz

Anal. Methods, 2016, 8, 6023
DOI: 10.1039/C6AY01154C

Direct mass spectrometry analysis of untreated samples of ultralow amounts using extraction nano-electrospray

Yue Ren, Jiangjiang Liu, Linfan Li, Morgan N. McLuckey and Zheng Ouyang

Anal. Methods, 2013, 5, 6686
DOI: 10.1039/c3ay41149d

Biosensors and nanobiosensors for therapeutic drug and response monitoring

Kristy S. McKeating, Alexandra Aubé and Jean-Francois Masson

Analyst, 2016, 141, 429
DOI: 10.1039/C5AN01861G

Direct differentiation of whole blood for forensic serology analysis by thread spray mass spectrometry

Sierra Jackson, Benjamin S. Frey, Maia N. Bates, Devin J. Swiner and Abraham K. Badu-Tawiah

Analyst, 2020, 145, 5615
DOI: 10.1039/D0AN00857E

Emergency diagnosis made easy: matrix removal and analyte enrichment from raw saliva using paper-arrow mass spectrometry

Yufeng Zhou, Tung-Ting Sham, Cedric Boisdon, Barry L. Smith, Joanne C. Blair, Daniel B. Hawcutt and Simon Maher

Analyst, 2023, 148, 5366
DOI: 10.1039/D3AN00850A

Liquid extraction surface analysis field asymmetric waveform ion mobility spectrometry mass spectrometry for the analysis of dried blood spots

Rian L. Griffiths, Alex Dexter, Andrew J. Creese and Helen J. Cooper

Analyst, 2015, 140, 6879
DOI: 10.1039/C5AN00933B

A diagnostic test for cocaine and benzoylecgonine in urine and oral fluid using portable mass spectrometry

Mahado Ismail, Mark Baumert, Derek Stevenson, John Watts, Roger Webb, Catia Costa, Fiona Robinson and Melanie Bailey

Anal. Methods, 2017, 9, 1839
DOI: 10.1039/C6AY02006B

Paper cone spray ionization mass spectrometry (PCSI MS) for simple and rapid analysis of raw solid samples

Purum Kim and Sangwon Cha

Analyst, 2015, 140, 5868
DOI: 10.1039/C5AN01062D

Qualitative analysis of designer drugs by paper spray ionisation mass spectrometry (PSI-MS)

Thays C. Carvalho, Izabela F. Oliveira, Lilian V. Tose, Gabriela Vanini, Jade B. Kill, Alvaro C. Neto, Leandro F. Machado, João C. L. Ambrosio, Valdemar Lacerda, Boniek G. Vaz and Wanderson Romão

Anal. Methods, 2016, 8, 614
DOI: 10.1039/C5AY01265A

Metal–organic framework coated paper substrates for paper spray mass spectrometry

Xiaoting Wang, Yajun Zheng, Teng Wang, Xingchuang Xiong, Xiang Fang and Zhiping Zhang

Anal. Methods, 2016, 8, 8004
DOI: 10.1039/C6AY02123A

Drug screening method development for paper spray coupled to a triple quadrupole mass spectrometer

Rachel Jett, Christine Skaggs and Nicholas E. Manicke

Anal. Methods, 2017, 9, 5037
DOI: 10.1039/C7AY01009E

Encapsulating chromogenic reaction substrates with porous hydrogel scaffolds onto arrayed capillary tubes toward a visual and high-throughput colorimetric strategy for rapid occult blood tests

Yao Jiang, Zongzhao Sun, Liyan Zhang, Yuchun Qiao, Fengjuan Liu, Yuanyuan Cai, Wenwen Zhang, Qianqian Zhang, Zhiqiang Duan and Hua Wang

J. Mater. Chem. B, 2017, 5, 1159
DOI: 10.1039/C6TB02836E

Direct analysis of herbicides by paper spray ionization mass spectrometry

Steven L. Reeber, Sneha Gadi, Sung-Ben Huang and Gary L. Glish

Anal. Methods, 2015, 7, 9808
DOI: 10.1039/C5AY02125A

Sheath-flow probe electrospray ionization (sfPESI) mass spectrometry for the rapid forensic analysis of human body fluids

Stephanie Rankin-Turner, Satoshi Ninomiya, James C. Reynolds and Kenzo Hiraoka

Anal. Methods, 2019, 11, 3633
DOI: 10.1039/C9AY00698B

Assessment of paper tip angular position, carryover, matrix effects and dried blood spot storage effect on paper spray mass spectrometry

John Takyi-Williams, Wenying Jian, Yang Wang, Kai Tang, Haiqing Gong and Chuan-Fa Liu

Anal. Methods, 2020, 12, 747
DOI: 10.1039/C9AY02128K

Direct analysis of drugs in forensic applications using laser ablation electrospray ionization-tandem mass spectrometry (LAESI-MS/MS)

Robert E. Deimler, Trust T. Razunguzwa, Brent R. Reschke, Callee M. Walsh, Matthew J. Powell and Glen P. Jackson

Anal. Methods, 2014, 6, 4810
DOI: 10.1039/C4AY01043D

Raspberry-Pi based system for propofol monitoring

Francesca Stradolini, Abuduwaili Tuoheti, Tugba Kilic, Danilo Demarchi and Sandro Carrara

Integration, 2018, 63, 213
DOI: 10.1016/j.vlsi.2018.04.004

Ambient ionization mass spectrometry for food analysis: Recent progress and applications

Yueguang Lv, Jiayu Zhao, Hongyu Xue and Qiang Ma

TrAC Trends in Analytical Chemistry, 2024, 178, 117814
DOI: 10.1016/j.trac.2024.117814

Reinventing (Bio)chemical Analysis with Paper

G. IJ. Salentijn, M. Grajewski and E. Verpoorte

Anal. Chem., 2018, 90, 13815
DOI: 10.1021/acs.analchem.8b04825

Fiber spray ionization mass spectrometry in forensic chemistry: A screening of drugs of abuse and direct determination of cocaine in urine

João Francisco Allochio Filho, Nayara A. dos Santos, Keyller Bastos Borges, Valdemar Lacerda, Fabrício Souza Pelição and Wanderson Romão

Rapid Comm Mass Spectrometry, 2020, 34
DOI: 10.1002/rcm.8747

Identification and Mitigation of Pyrolysis Products in Laser-Cut Paper for Paper Spray Mass Spectrometry

Magnus Rydberg, Alexis Ochoa, Katherine Dayana Barrera Campos, Christine Skaggs, Ashur Rael and Nicholas Manicke

J. Am. Soc. Mass Spectrom., 2025, 36, 829
DOI: 10.1021/jasms.4c00499

Detection of low-quantity anticancer drugs by surface-enhanced Raman scattering

Lucio Litti, Vincenzo Amendola, Giuseppe Toffoli and Moreno Meneghetti

Anal Bioanal Chem, 2016, 408, 2123
DOI: 10.1007/s00216-016-9315-4

Direct and rapid quantitation of ephedrines in human urine by paper spray ionization/high resolution mass spectrometry

Eun Sook Jeong, Ki Hun Kim, Eunju Cha, Oh-Seung Kwon, Sangwon Cha and Jaeick Lee

Journal of Chromatography B, 2016, 1028, 237
DOI: 10.1016/j.jchromb.2016.06.040

Electrospray ionization using a bamboo pen nib

Hsin-Kai Chen, Chien-Hung Lin, Ju-Tsung Liu and Cheng-Huang Lin

International Journal of Mass Spectrometry, 2013, 356, 37
DOI: 10.1016/j.ijms.2013.09.016

Rapid assay of resveratrol in red wine by paper spray tandem mass spectrometry and isotope dilution

Leonardo Di Donna, Domenico Taverna, Serena Indelicato, Anna Napoli, Giovanni Sindona and Fabio Mazzotti

Food Chemistry, 2017, 229, 354
DOI: 10.1016/j.foodchem.2017.02.098

Analysis of Biological Samples Using Paper Spray Mass Spectrometry: An Investigation of Impacts by the Substrates, Solvents and Elution Methods

Yue Ren, He Wang, Jiangjiang Liu, Zhiping Zhang, Morgan N. McLuckey and Zheng Ouyang

Chromatographia, 2013, 76, 1339
DOI: 10.1007/s10337-013-2458-y

New Mass Spectrometric Approaches for the Quantitative Evaluation of Anticancer Drug Levels in Treated Patients

Sara D'Aronco, Edoardo D'Angelo, Sara Crotti, Pietro Traldi and Marco Agostini

Therapeutic Drug Monitoring, 2019, 41, 1
DOI: 10.1097/FTD.0000000000000573

Assessment of creatinine concentration in whole blood spheroids using paper spray ionization–tandem mass spectrometry

Tung-Ting Sham, Abraham K. Badu-Tawiah, Stephen J. McWilliam and Simon Maher

Sci Rep, 2022, 12
DOI: 10.1038/s41598-022-18365-8

Analysis of Biofluids by Paper Spray-MS in Forensic Toxicology

Ana Luiza Freitas de Assis Linhares and Mauricio Yonamine

Bioanalysis, 2020, 12, 1087
DOI: 10.4155/bio-2020-0160

Ambient Ionization Mass Spectrometry for Point-of-Care Diagnostics and Other Clinical Measurements

Christina R Ferreira, Karen E Yannell, Alan K Jarmusch, Valentina Pirro, Zheng Ouyang and R Graham Cooks

Clinical Chemistry, 2016, 62, 99
DOI: 10.1373/clinchem.2014.237164

Simultaneous Quantitation of Multiple Biological Thiols Using Reactive Ionization and Derivatization with Charged Mass Tags

Mousumi Saha, Lingqi Qiu, Yu Han-Hallett, Christopher J. Welch and R. Graham Cooks

Anal. Chem., 2024, 96, 19414
DOI: 10.1021/acs.analchem.4c03807

Development of a prototype blood fractionation cartridge for plasma analysis by paper spray mass spectrometry

Brandon J. Bills and Nicholas E. Manicke

Clinical Mass Spectrometry, 2016, 2, 18
DOI: 10.1016/j.clinms.2016.12.002

Recent advances in low‐cost microfluidic platforms for diagnostic applications

Wendell Karlos Tomazelli Coltro, Chao‐Min Cheng, Emanuel Carrilho and Dosil Pereira de Jesus

Electrophoresis, 2014, 35, 2309
DOI: 10.1002/elps.201400006

A statistical approach to optimizing paper spray mass spectrometry parameters

Christine Skaggs, Lindsey Kirkpatrick, William R.A. Wichert, Nicole Skaggs and Nicholas E. Manicke

Rapid Comm Mass Spectrometry, 2020, 34
DOI: 10.1002/rcm.8601

Quantitative analysis of finasteride tablets dissolution content with non‐isotopically labeled internal standard by paper spray ionization mass spectrometry

Yang Liu, Yanan Zhou, Yandong Dai, Zhuang Zhao, Lan He and Qingsheng Zhang

J of Separation Science, 2018, 41, 4083
DOI: 10.1002/jssc.201800606

Miniature mass spectrometer–based point-of-care assay for cabotegravir and rilpivirine in whole blood

Sangeeta Pandey, Yanyang Hu, Lane R. Bushman, Jose Castillo-Mancilla, Peter L. Anderson and R. Graham Cooks

Anal Bioanal Chem, 2022, 414, 3387
DOI: 10.1007/s00216-022-03954-3

Electrophoresis-enhanced paper spray mass spectrometry

Dylan T. Holden, Brison A. Shira, MyPhuong T. Le and R. Graham Cooks

Talanta, 2025, 293, 128099
DOI: 10.1016/j.talanta.2025.128099

Using Sesame Seed Oil to Preserve and Preconcentrate Cannabinoids for Paper Spray Mass Spectrometry

Brandon Bills and Nicholas Manicke

J. Am. Soc. Mass Spectrom., 2020, 31, 675
DOI: 10.1021/jasms.9b00113

Comparison of uncoated vs superhydrophobic copper surfaces for metal spray ionization

Michael C. Godwin and William D. Hoffmann

International Journal of Mass Spectrometry, 2020, 452, 116339
DOI: 10.1016/j.ijms.2020.116339

Development of Coated Blade Spray Ionization Mass Spectrometry for the Quantitation of Target Analytes Present in Complex Matrices

German Augusto Gómez‐Ríos and Janusz Pawliszyn

Angew Chem Int Ed, 2014, 53, 14503
DOI: 10.1002/anie.201407057

Rapid measurement of tacrolimus in whole blood by paper spray-tandem mass spectrometry (PS-MS/MS)

Run-Zhang Shi, El Taher M. El Gierari, Nicholas E. Manicke and James D. Faix

Clinica Chimica Acta, 2015, 441, 99
DOI: 10.1016/j.cca.2014.12.022

On the Slow Diffusion of Point-of-Care Systems in Therapeutic Drug Monitoring

Barbara Sanavio and Silke Krol

Front. Bioeng. Biotechnol., 2015, 3
DOI: 10.3389/fbioe.2015.00020

Spray mechanism in paper spray ionization

Ryan D. Espy, Ariel R. Muliadi, Zheng Ouyang and R. Graham Cooks

International Journal of Mass Spectrometry, 2012, 325-327, 167
DOI: 10.1016/j.ijms.2012.06.017

Internal Standard Utilization Strategies for Quantitative Paper Spray Mass Spectrometry

Lucas R. Abruzzi, John-Clare Laxton, Taelor M. Zarkovic and Chris G. Gill

J. Am. Soc. Mass Spectrom., 2025, 36, 1167
DOI: 10.1021/jasms.5c00036

in vitro Selection of Aptamer for Imidacloprid Recognition as Model Analyte and Construction of a Water Analysis Platform

Gulsah Bor, Ezgi Man, Ozge Ugurlu, Ayse Elcin Ceylan, Simge Balaban, Ceren Durmus, Z. Pinar Gumus, Serap Evran and Suna Timur

Electroanalysis, 2020, 32, 1922
DOI: 10.1002/elan.202000075

The “Bloodless” Blood Test: Intradermal Prick Nanoelectronics for the Blood Extraction-Free Multiplex Detection of Protein Biomarkers

Nimrod Harpak, Ella Borberg, Adva Raz and Fernando Patolsky

ACS Nano, 2022, 16, 13800
DOI: 10.1021/acsnano.2c01793

Paper spray ionization mass spectrometry: recent advances and clinical applications

Spencer Chiang, Wenpeng Zhang and Zheng Ouyang

Expert Review of Proteomics, 2018, 15, 781
DOI: 10.1080/14789450.2018.1525295

Ambient Ionization Mass Spectrometry Measurement of Aminotransferase Activity

Xin Yan, Xin Li, Chengsen Zhang, Yang Xu and R. Graham Cooks

J. Am. Soc. Mass Spectrom., 2017, 28, 1175
DOI: 10.1007/s13361-016-1591-x

The impacts of paper properties on matrix effects during paper spray mass spectrometry analysis of prescription drugs, fentanyl and synthetic cannabinoids

Brandon J. Bills, Jeffrey Kinkade, Greta Ren and Nicholas E. Manicke

Forensic Chemistry, 2018, 11, 15
DOI: 10.1016/j.forc.2018.08.002

Rapid analysis of drug dissolution by paper spray ionization mass spectrometry

Yang Liu, Ning Liu, Ya-nan Zhou, Lan Lin and Lan He

Journal of Pharmaceutical and Biomedical Analysis, 2017, 136, 106
DOI: 10.1016/j.jpba.2016.12.025

Chromatographic and mass spectrometric analytical strategies for profiling tyrosine kinase inhibitors in biological samples

Jing Ye, Mengxin Bi, Huan Yao, Deliang Yang and Di Chen

Microchemical Journal, 2024, 201, 110694
DOI: 10.1016/j.microc.2024.110694

On-Surface Alcohol Oxidation Monitored by Paper Spray Mass Spectrometry: The Role of Ruthenium as Catalyst

João Victor Coelho Pimenta, Rodinei Augusti and Adão Aparecido Sabino

J. Am. Soc. Mass Spectrom., 2021, 32, 2168
DOI: 10.1021/jasms.1c00125

In Situ Separation and Analysis of Lipids by Paper Spray Ionization Mass Spectrometry

Youngju Kal and Sangwon Cha

Molecules, 2020, 26, 93
DOI: 10.3390/molecules26010093

Mini 12, Miniature Mass Spectrometer for Clinical and Other Applications—Introduction and Characterization

Linfan Li, Tsung-Chi Chen, Yue Ren, Paul I. Hendricks, R. Graham Cooks and Zheng Ouyang

Anal. Chem., 2014, 86, 2909
DOI: 10.1021/ac403766c

Opening the toolbox of alternative sampling strategies in clinical routine: A key-role for (LC-)MS/MS

Sofie Velghe, Sara Capiau and Christophe P. Stove

TrAC Trends in Analytical Chemistry, 2016, 84, 61
DOI: 10.1016/j.trac.2016.01.030

Direct ionization methods in mass spectrometry: An overview

Christian W. Klampfl and Markus Himmelsbach

Analytica Chimica Acta, 2015, 890, 44
DOI: 10.1016/j.aca.2015.07.012

Use of Nanoparticle Decorated Surface-Enhanced Raman Scattering Active Sol–Gel Substrates for SALDI-MS Analysis

Andrew E. Paulson, W. Ranjith Premasiri, Lawrence D. Ziegler and Young Jin Lee

J. Am. Soc. Mass Spectrom., 2023, 34, 273
DOI: 10.1021/jasms.2c00285

Direct Analysis and Quantification of Metaldehyde in Water using Reactive Paper Spray Mass Spectrometry

Simon Maher, Fred P. M. Jjunju, Deidre E. Damon, Hannah Gorton, Yosef S. Maher, Safaraz U. Syed, Ron M. A. Heeren, Iain S. Young, Stephen Taylor and Abraham K. Badu-Tawiah

Sci Rep, 2016, 6
DOI: 10.1038/srep35643

Paper Spray Ionization Coupled to High Resolution Tandem Mass Spectrometry for Comprehensive Urine Drug Testing in Comparison to Liquid Chromatography-Coupled Techniques after Urine Precipitation or Dried Urine Spot Workup

Julian A. Michely, Markus R. Meyer and Hans H. Maurer

Anal. Chem., 2017, 89, 11779
DOI: 10.1021/acs.analchem.7b03398

Acoustofluidic Actuation of Living Cells

Yue Wu, Junyang Gai, Yuwen Zhao, Yi Liu and Yaling Liu

Micromachines, 2024, 15, 466
DOI: 10.3390/mi15040466

Rapid analysis of benzalkonium chloride using paper spray mass spectrometry

Jingjing Liu, Wenjie Deng, Muqian Yu, Ruizhi Wen, Shouzhuo Yao and Bo Chen

Journal of Pharmaceutical and Biomedical Analysis, 2017, 145, 151
DOI: 10.1016/j.jpba.2017.06.030

Differential Rapid Screening of Phytochemicals by Leaf Spray Mass Spectrometry

Thomas Muller and R. Graham Cooks

Bulletin of the Korean Chemical Society, 2014, 35, 919
DOI: 10.5012/bkcs.2014.35.3.919

Therapeutic Drug Monitoring of Pazopanib in Renal Cell Carcinoma and Soft Tissue Sarcoma: A Systematic Review

Miroslav Turjap, Marta Pelcová, Jana Gregorová, Pavel Šmak, Hiroko Martin, Jan Štingl, Ondřej Peš and Jan Juřica

Therapeutic Drug Monitoring, 2024, 46, 321
DOI: 10.1097/FTD.0000000000001206

Direct Ionization of Solid-Phase Microextraction Fibers for Quantitative Drug Bioanalysis: From Peripheral Circulation to Mass Spectrometry Detection

Sheelan Ahmad, Michael Tucker, Neil Spooner, Darragh Murnane and Ute Gerhard

Anal. Chem., 2015, 87, 754
DOI: 10.1021/ac503706n

Paper spray ionization mass spectrometry: Study of a method for fast-screening analysis of pesticides in fruits and vegetables

Hanno Evard, Anneli Kruve, Rünno Lõhmus and Ivo Leito

Journal of Food Composition and Analysis, 2015, 41, 221
DOI: 10.1016/j.jfca.2015.01.010

Field-Assisted Paper Spray Mass Spectrometry for the Quantitative Evaluation of Imatinib Levels in Plasma

Sara D'Aronco, Eleonora Calandra, Sara Crotti, Giuseppe Toffoli, Elena Marangon, Bianca Posocco, Pietro Traldi and Marco Agostini

Eur J Mass Spectrom (Chichester), 2016, 22, 217
DOI: 10.1255/ejms.1437

Automatically High-Throughput Quantification by Paper Spray Ionization Mass Spectrometry for Multiple Pesticides in Wine

Tianyang Guo, Wei Yong and Yiyang Dong

Food Anal. Methods, 2019, 12, 1208
DOI: 10.1007/s12161-019-01450-6

Field‐assisted paper spray mass spectrometry for therapeutic drug monitoring: 1. the case of imatinib in plasma

S. D'Aronco, M. Dall'Armi, S. Crotti, E. Calandra, P. Traldi, V. Di Marco, A. Buonadonna, G. Corona, L. Giodini, E. Marangon, B. Posocco, G. Toffoli and M. Agostini

J. Mass Spectrom., 2017, 52, 283
DOI: 10.1002/jms.3927

Rapid analysis of benzoic acid and vitamin C in beverages by paper spray mass spectrometry

Muqian Yu, Ruizhi Wen, Le Jiang, Si Huang, Zhengfa Fang, Bo Chen and Liping Wang

Food Chemistry, 2018, 268, 411
DOI: 10.1016/j.foodchem.2018.06.103

Emerging trends in paper spray mass spectrometry: Microsampling, storage, direct analysis, and applications

Benjamin S. Frey, Deidre E. Damon and Abraham K. Badu‐Tawiah

Mass Spectrometry Reviews, 2020, 39, 336
DOI: 10.1002/mas.21601

Paper spray screening and liquid chromatography/mass spectrometry confirmation for medication adherence testing: A two‐step process

Catia Costa, Cecile Frampas, Katherine A. Longman, Vladimir Palitsin, Mahado Ismail, Patrick Sears, Ramin Nilforooshan and Melanie J. Bailey

Rapid Comm Mass Spectrometry, 2021, 35
DOI: 10.1002/rcm.8553

Fast quantitative analysis of four tyrosine kinase inhibitors in different human plasma samples using three-way calibration- assisted liquid chromatography with diode array detection

Shou-Xia Xiang, Hai-Long Wu, Chao Kang, Li-Xia Xie, Xiao-Li Yin, Hui-Wen Gu and Ru-Qin Yu

J. Sep. Science, 2015, 38, 2781
DOI: 10.1002/jssc.201500391

Electrospray ionization with aluminum foil: A versatile mass spectrometric technique

Bin Hu, Pui-Kin So and Zhong-Ping Yao

Analytica Chimica Acta, 2014, 817, 1
DOI: 10.1016/j.aca.2014.02.005

Paper Spray-MS for Bioanalysis

Cheng-Huang Lin, Wei-Ching Liao, Hsin-Kai Chen and Ting-Yang Kuo

Bioanalysis, 2014, 6, 199
DOI: 10.4155/bio.13.310

Paper Spray and Extraction Spray Mass Spectrometry for the Direct and Simultaneous Quantification of Eight Drugs of Abuse in Whole Blood

Ryan D. Espy, Sebastiaan Frans Teunissen, Nicholas E. Manicke, Yue Ren, Zheng Ouyang, Arian van Asten and R. Graham Cooks

Anal. Chem., 2014, 86, 7712
DOI: 10.1021/ac5016408

Sponge Spray—Reaching New Dimensions of Direct Sampling and Analysis by MS

Max Hecht, Hanno Evard, Kalev Takkis, Ru̅ta Veigure, Rudolf Aro, Rynno Lohmus, Koit Herodes, Ivo Leito and Karin Kipper

Anal. Chem., 2017, 89, 11592
DOI: 10.1021/acs.analchem.7b02957

Characterization and Analysis of Paper Spray Ionization of Organic Compounds

Hugo Aliaga-Aguilar

J. Am. Soc. Mass Spectrom., 2018, 29, 17
DOI: 10.1007/s13361-017-1826-5

Coupling paper spray ionization with the flexible microtube plasma for the determination of low polar biomarkers in mass spectrometry

Daniel Foest, Alexander Knodel, Sebastian Brandt and Joachim Franzke

Analytica Chimica Acta, 2022, 1201, 339619
DOI: 10.1016/j.aca.2022.339619

Development of a Paper Spray Mass Spectrometry Cartridge with Integrated Solid Phase Extraction for Bioanalysis

Chengsen Zhang and Nicholas E. Manicke

Anal. Chem., 2015, 87, 6212
DOI: 10.1021/acs.analchem.5b00884

Paper spray mass spectrometry: A new drug checking tool for harm reduction in the opioid overdose crisis

Gregory W. Vandergrift and Chris G. Gill

J Mass Spectrom, 2019, 54, 729
DOI: 10.1002/jms.4431

Accelerated nucleophilic substitution reactions of dansyl chloride with aniline under ambient conditions via dual-tip reactive paper spray

Norfatirah Muhamad Sarih, David Romero-Perez, Behnam Bastani, Monrawat Rauytanapanit, Cedric Boisdon, Thanit Praneenararat, Hairul Anuar Tajuddin, Zanariah Abdullah, Abraham K. Badu-Tawiah and Simon Maher

Sci Rep, 2020, 10
DOI: 10.1038/s41598-020-78133-4

The ten principles of green sample preparation

Ángela I. López-Lorente, Francisco Pena-Pereira, Stig Pedersen-Bjergaard, Vânia G. Zuin, Sibel A. Ozkan and Elefteria Psillakis

TrAC Trends in Analytical Chemistry, 2022, 148, 116530
DOI: 10.1016/j.trac.2022.116530

Direct Analysis of Samples of Various Origin and Composition Using Specific Types of Mass Spectrometry

Hubert Byliński, Jacek Gębicki, Tomasz Dymerski and Jacek Namieśnik

Critical Reviews in Analytical Chemistry, 2017, 47, 340
DOI: 10.1080/10408347.2017.1298986

Analysis of Drugs in Whole Blood by Paper Spray Mass Spectrometry with Integrated Solid-Phase Extraction

Greta Ren, Brandon J. Bills and Nicholas E. Manicke

Anal. Chem., 2025, 97, 14004
DOI: 10.1021/acs.analchem.5c02394

Direct Quantitative Analysis of Nicotine Alkaloids from Biofluid Samples using Paper Spray Mass Spectrometry

He Wang, Yue Ren, Morgan N. McLuckey, Nicholas E. Manicke, Jonghyuck Park, Lingxing Zheng, Riyi Shi, R. Graham Cooks and Zheng Ouyang

Anal. Chem., 2013, 85, 11540
DOI: 10.1021/ac402798m

Development of Coated Blade Spray Ionization Mass Spectrometry for the Quantitation of Target Analytes Present in Complex Matrices

German Augusto Gómez‐Ríos and Janusz Pawliszyn

Angewandte Chemie, 2014, 126, 14731
DOI: 10.1002/ange.201407057

Comparison of paper spray mass spectrometry analysis of dried blood spots from devices used for in-field collection of clinical samples

Karen E. Yannell, Kristina R. Kesely, Huynh Dinh Chien, Candice B. Kissinger and R. Graham Cooks

Anal Bioanal Chem, 2017, 409, 121
DOI: 10.1007/s00216-016-9954-5

Evaluation of novel organosilane modifications of paper spray mass spectrometry substrates for analyzing polar compounds

Thomas P. Bambauer, Hans H. Maurer, Armin A. Weber, Matthias Hannig, Norbert Pütz, Marcus Koch, Sascha K. Manier, Marc Schneider and Markus R. Meyer

Talanta, 2019, 204, 677
DOI: 10.1016/j.talanta.2019.05.095

Mass Spectrometry Methods for In Situ Analysis of Clinical Biomolecules

Wen Ma, Shuting Xu, Huwei Liu and Yu Bai

Small Methods, 2020, 4
DOI: 10.1002/smtd.201900407

State-Of-The-Art Dried Blood Spot Analysis: an Overview of Recent Advances and Future Trends

Roland JW Meesters and Gero P Hooff

Bioanalysis, 2013, 5, 2187
DOI: 10.4155/bio.13.175

3D-Printed Paper Spray Ionization Cartridge with Fast Wetting and Continuous Solvent Supply Features

Gert IJ. Salentijn, Hjalmar P. Permentier and Elisabeth Verpoorte

Anal. Chem., 2014, 86, 11657
DOI: 10.1021/ac502785j

New urea-modified paper substrate for enhanced analytical performance of negative ion mode paper spray mass spectrometry

Jingjing Liu, Yan He, Shuo Chen, Ming Ma, Shouzuo Yao and Bo Chen

Talanta, 2017, 166, 306
DOI: 10.1016/j.talanta.2017.01.076

A Small Footprint and Robust Interface for Solid Phase Microextraction and Mass Spectrometry Based on Vibrating Sharp-Edge Spray Ionization

Jing Wang, Chong Li and Peng Li

J. Am. Soc. Mass Spectrom., 2022, 33, 304
DOI: 10.1021/jasms.1c00305

The use of mass spectrometry to analyze dried blood spots

Michel Wagner, David Tonoli, Emmanuel Varesio and Gérard Hopfgartner

Mass Spectrometry Reviews, 2016, 35, 361
DOI: 10.1002/mas.21441

Molecularly imprinted polymer (MIP) membrane assisted direct spray ionization mass spectrometry for agrochemicals screening in foodstuffs

Igor Pereira, Marcella Ferreira Rodrigues, Andréa Rodrigues Chaves and Boniek Gontijo Vaz

Talanta, 2018, 178, 507
DOI: 10.1016/j.talanta.2017.09.080

Exploring a route to a selective and sensitive portable system for explosive detection– swab spray ionisation coupled to of high-field assisted waveform ion mobility spectrometry (FAIMS)

C. Costa, E.M. van Es, P. Sears, J. Bunch, Vladimir Palitsin, H. Cooper and M.J. Bailey

Forensic Science International: Synergy, 2019, 1, 214
DOI: 10.1016/j.fsisyn.2019.07.009

Schirmer Paper Noninvasive Microsampling for Direct Mass Spectrometry Analysis of Human Tears

Ya-Nan Yao, Dandan Di, Zi-Cheng Yuan, Lin Wu and Bin Hu

Anal. Chem., 2020, 92, 6207
DOI: 10.1021/acs.analchem.9b05078

Chemical analysis and chemical imaging of fragrances and volatile compounds by low‐temperature plasma ionization mass spectrometry

Dahlia I. Campbell, Jon K. Dalgleish, Ismael Cotte‐Rodriguez, Shuji Maeno and R. Graham Cooks

Rapid Comm Mass Spectrometry, 2013, 27, 1828
DOI: 10.1002/rcm.6632

Evaluating bioanalytical capabilities of paper spray ionization for abiraterone drug quantification in patient plasma

Atul Bhatnagar, Matthew J. McKay, Malmaruha Arasaratnam, Megan Crumbaker, Howard Gurney and Mark P. Molloy

J Mass Spectrom, 2020, 55
DOI: 10.1002/jms.4584

Ionization Suppression and Recovery in Direct Biofluid Analysis Using Paper Spray Mass Spectrometry

Carolina Vega, Corina Spence, Chengsen Zhang, Brandon J. Bills and Nicholas E. Manicke

J. Am. Soc. Mass Spectrom., 2016, 27, 726
DOI: 10.1007/s13361-015-1322-8

Paper spray mass spectrometry – A potential complementary technique for the detection of polar compounds in sports drug testing

Christian Görgens, Katherine Walker, Cornelia Boeser, Neloni Wijeratne, Claudia Martins, Sven Guddat and Mario Thevis

Drug Testing and Analysis, 2020, 12, 1658
DOI: 10.1002/dta.2909

Plasma drug screening using paper spray mass spectrometry with integrated solid phase extraction

Hannah Zimmerman‐Federle, Greta Ren, Sarah Dowling, Cassandra Warren, Daniel Rusyniak, Robert Avera and Nicholas E. Manicke

Drug Testing and Analysis, 2025, 17, 138
DOI: 10.1002/dta.3687

Analysis of Biofluids by Paper Spray MS: Advances and Challenges

Nicholas E Manicke, Brandon J Bills and Chengsen Zhang

Bioanalysis, 2016, 8, 589
DOI: 10.4155/bio-2015-0018

High-Throughput Screening and Quantitation of Target Compounds in Biofluids by Coated Blade Spray-Mass Spectrometry

Marcos Tascon, Germán Augusto Gómez-Ríos, Nathaly Reyes-Garcés, Justen Poole, Ezel Boyacı and Janusz Pawliszyn

Anal. Chem., 2017, 89, 8421
DOI: 10.1021/acs.analchem.7b01877

Direct whole blood analysis by the antigen-antibody chemically-delayed dissociation from nanosensors arrays

Marina Zverzhinetsky, Vadim Krivitsky and Fernando Patolsky

Biosensors and Bioelectronics, 2020, 170, 112658
DOI: 10.1016/j.bios.2020.112658

On-surface multicomponent Povarov reaction examined by paper spray mass spectrometry

João Victor Coelho Pimenta, Adão Aparecido Sabino and Rodinei Augusti

International Journal of Mass Spectrometry, 2022, 472, 116775
DOI: 10.1016/j.ijms.2021.116775

Development and validation of a paper spray mass spectrometry method for the rapid quantitation of remdesivir and its active metabolite, GS-441524, in human plasma

Christine Skaggs, Hannah Zimmerman, Nicholas Manicke and Lindsey Kirkpatrick

Journal of Mass Spectrometry and Advances in the Clinical Lab, 2022, 25, 27
DOI: 10.1016/j.jmsacl.2022.06.001

Simultaneous quantitation of five triazole anti-fungal agents by paper spray-mass spectrometry

Christine L. Skaggs, Greta J. Ren, El Taher M. Elgierari, Lillian R. Sturmer, Run Z. Shi, Nicholas E. Manicke and Lindsey M. Kirkpatrick

Clinical Chemistry and Laboratory Medicine (CCLM), 2020, 58, 836
DOI: 10.1515/cclm-2019-0895

Mass spectrometry in the pharmacokinetic studies of anticancer natural products

Sara Crotti, Bianca Posocco, Elena Marangon, Donato Nitti, Giuseppe Toffoli and Marco Agostini

Mass Spectrometry Reviews, 2017, 36, 213
DOI: 10.1002/mas.21478

Determining Surface Energy of Porous Substrates by Spray Ionization

Deidre E. Damon, Yosef S. Maher, Danyelle M. Allen, Jill Baker, Boyce S. Chang, Simon Maher, Martin M. Thuo and Abraham K. Badu-Tawiah

Langmuir, 2019, 35, 13853
DOI: 10.1021/acs.langmuir.9b02419

Fast, Sensitive, and Quantitative Point-of-Care Platform for the Assessment of Drugs of Abuse in Urine, Serum, and Whole Blood

Ying Li, Uvaraj Uddayasankar, Bangshun He, Ping Wang and Lidong Qin

Anal. Chem., 2017, 89, 8273
DOI: 10.1021/acs.analchem.7b01288

Paper Spray Mass Spectrometry for the Forensic Analysis of Black Ballpoint Pen Inks

Victoria Silva Amador, Hebert Vinicius Pereira, Marcelo Martins Sena, Rodinei Augusti and Evandro Piccin

J. Am. Soc. Mass Spectrom., 2017, 28, 1965
DOI: 10.1007/s13361-017-1686-z

Paper spray ionization: Applications and perspectives

Ethan M. McBride, Phillip M. Mach, Elizabeth S. Dhummakupt, Sarah Dowling, Daniel O. Carmany, Paul S. Demond, Gabrielle Rizzo, Nicholas E. Manicke and Trevor Glaros

TrAC Trends in Analytical Chemistry, 2019, 118, 722
DOI: 10.1016/j.trac.2019.06.028

Cross-validation of a mass spectrometric-based method for the therapeutic drug monitoring of irinotecan: implementation of matrix-assisted laser desorption/ionization mass spectrometry in pharmacokinetic measurements

Eleonora Calandra, Bianca Posocco, Sara Crotti, Elena Marangon, Luciana Giodini, Donato Nitti, Giuseppe Toffoli, Pietro Traldi and Marco Agostini

Anal Bioanal Chem, 2016, 408, 5369
DOI: 10.1007/s00216-016-9634-5

Ambient Ionization-Paper Spray Ionization and Its Application

Zhi-Ping ZHANG, Xiao-Ning LIU and Ya-Jun ZHENG

Chinese Journal of Analytical Chemistry, 2014, 42, 145
DOI: 10.1016/S1872-2040(13)60706-9

Rapid and Reagent-Free Analysis of Dried Blood Spot by Paper Spray Mass Spectrometry Reveals Sex: Implications in Forensic Investigations

Supratim Mondal, Uddeshya Pandey, Sourik Chakrabarti, Pragya Pahchan, Debasish Koner and Shibdas Banerjee

J. Proteome Res., 2025, 24, 2314
DOI: 10.1021/acs.jproteome.4c00798

Toxicological Drug Screening using Paper Spray High-Resolution Tandem Mass Spectrometry (HR-MS/MS)

Josiah McKenna, Rachel Jett, Kevin Shanks and Nicholas E Manicke

Journal of Analytical Toxicology, 2018, 42, 300
DOI: 10.1093/jat/bky001

Recent advances in on-site mass spectrometry analysis for clinical applications

Xiaoyu Zhou, Wenpeng Zhang and Zheng Ouyang

TrAC Trends in Analytical Chemistry, 2022, 149, 116548
DOI: 10.1016/j.trac.2022.116548

Point-of-Care Tissue Analysis Using Miniature Mass Spectrometer

Ran Zou, Wenbo Cao, Leelyn Chong, Wei Hua, Hao Xu, Ying Mao, Jessica Page, Riyi Shi, Yu Xia, Tony Y. Hu, Wenpeng Zhang and Zheng Ouyang

Anal. Chem., 2019, 91, 1157
DOI: 10.1021/acs.analchem.8b04935

Fast analysis of caffeine in beverages and drugs by paper spray tandem mass spectrometry

Domenico Taverna, Leonardo Di Donna, Lucia Bartella, Anna Napoli, Giovanni Sindona and Fabio Mazzotti

Anal Bioanal Chem, 2016, 408, 3783
DOI: 10.1007/s00216-016-9468-1

LC–MS/MS as a tool for TDM services: Where are we?

Maria Shipkova and Dobrin Svinarov

Clinical Biochemistry, 2016, 49, 1009
DOI: 10.1016/j.clinbiochem.2016.05.001

Polymer substrate with surface solvent reservoir for polymer-spray mass spectrometric analysis of hydrophilic drugs

Maria T. Dulay, Cornelia L. Boeser, Katherine L. Walker, Clara Feider and Richard N. Zare

Talanta Open, 2021, 4, 100048
DOI: 10.1016/j.talo.2021.100048

Zero volt paper spray ionization mass spectrometry for direct analysis of samples on filter paper substrate

Akira Motoyama and Keishi Kihara

Rapid Commun. Mass Spectrom., 2015, 29, 1905
DOI: 10.1002/rcm.7292

Paperspray Ionization Mass Spectrometry as a Tool for Predicting Real-Time Optimized Dosing of the Chemotherapeutic Drug Melphalan

Junfang Zhao, Chandra Sharat, Parinda A Mehta, Kana Mizuno, Alexander A Vinks and Kenneth D R Setchell

The Journal of Applied Laboratory Medicine, 2021, 6, 625
DOI: 10.1093/jalm/jfaa237

Conference Report: 60Th American Society For Ms Conference on Ms And Allied Topics

David Touboul, Alexandre Seyer and François Becher

Bioanalysis, 2012, 4, 2109
DOI: 10.4155/bio.12.196