Issue 37, 2021

Recent developments in synthesis of catechols by Dakin oxidation

Abstract

In recent years, Dakin oxidation has evolved primarily around the conversion of ortho- and para-hydroxy benzaldehydes and acetophenones to dihydric phenols, which are found in nature and complex organic materials. In the traditional Dakin reaction, an excess amount of NaOH was used along with hydrogen peroxide. The synthetic community has devoted much time and effort to developing efficient basic, acidic and neutral reaction media for Dakin oxidation. The use of in situ generated H2O2 and molecular oxygen was also tested as an alternative oxidant for this reaction. In this review, we will discuss recent developments in Dakin oxidation with representative examples as well as future challenges and potential applications for this exciting field.

Graphical abstract: Recent developments in synthesis of catechols by Dakin oxidation

Article information

Article type
Perspective
Submitted
07 jul 2021
Accepted
13 aug 2021
First published
16 aug 2021

New J. Chem., 2021,45, 17077-17084

Recent developments in synthesis of catechols by Dakin oxidation

P. Bora, B. Bora and U. Bora, New J. Chem., 2021, 45, 17077 DOI: 10.1039/D1NJ03300J

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