Issue 89, 2021

Iridium-catalyzed enantioselective addition of an N-methyl C–H bond to α-trifluoromethylstyrenes via C–H activation

Abstract

The Ir-catalyzed enantioselective addition of an N-methyl C–H bond of 2-(methylamino)pyridine derivatives to α-trifluoromethylstyrenes proceeded via C–H activation to give chiral γ-branched amine derivatives having a trifluoromethyl-substituted stereocenter. It was found that a bulky and electron-withdrawing group at the 3-position of 2-(methylamino)pyridines was necessary for the present C–H addition reaction catalyzed by a cationic iridium/chiral bisphosphine complex.

Graphical abstract: Iridium-catalyzed enantioselective addition of an N-methyl C–H bond to α-trifluoromethylstyrenes via C–H activation

Supplementary files

Article information

Article type
Communication
Submitted
09 sep 2021
Accepted
15 okt 2021
First published
15 okt 2021

Chem. Commun., 2021,57, 11787-11790

Iridium-catalyzed enantioselective addition of an N-methyl C–H bond to α-trifluoromethylstyrenes via C–H activation

D. Yamauchi, I. Nakamura and T. Nishimura, Chem. Commun., 2021, 57, 11787 DOI: 10.1039/D1CC05076A

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