Issue 12, 2019

Recent advances in reaction-based fluorescent probes for detecting monoamine oxidases in living systems

Abstract

Monoamine oxidase (MAO) is a membrane-bound mitochondrial enzyme that plays an important role by catalyzing oxidative deamination to maintain the homeostasis of neurotransmitters and other biogenic amines in living systems. MAO activity is critical for the brain and central nervous system. Its dysfunction is closely related with many neurological and psychiatric disorders. Fluorescent probes provide a useful approach to accurately detect MAO activity and assist to better elucidate their biological functions. Herein, in this Minireview, we summarize the recent advances in reaction based MAO type fluorescent probes and their imaging applications in living systems.

Graphical abstract: Recent advances in reaction-based fluorescent probes for detecting monoamine oxidases in living systems

Article information

Article type
Minireview
Submitted
03 mar 2019
Accepted
24 apr 2019
First published
24 apr 2019

Analyst, 2019,144, 3703-3709

Recent advances in reaction-based fluorescent probes for detecting monoamine oxidases in living systems

J. Huang, D. Hong, W. Lang, J. Liu, J. Dong, C. Yuan, J. Luo, J. Ge and Q. Zhu, Analyst, 2019, 144, 3703 DOI: 10.1039/C9AN00409B

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