Issue 67, 2013

Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers

Abstract

The structures of various urea oligomers incorporating one or two central achiral 1,2-diamino-1,1-dimethylethane (DADME) units have been investigated in solution and in the crystalline state. These diamine monomers are analogous to the achiral helicogenic amino acid Aib (α-aminoisobutyric acid). Oligomers were found to fold into helical conformations with DADME units inducing local deviations from the canonical helix geometry of urea foldamers.

Graphical abstract: Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers

Supplementary files

Article information

Article type
Communication
Submitted
04 feb 2013
Accepted
21 jun 2013
First published
21 jun 2013

Chem. Commun., 2013,49, 7415-7417

Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers

J. Fremaux, C. Dolain, B. Kauffmann, J. Clayden and G. Guichard, Chem. Commun., 2013, 49, 7415 DOI: 10.1039/C3CC40961A

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