Issue 40, 2024

Advancements in DNA computing: exploring DNA logic systems and their biomedical applications

Abstract

DNA computing is regarded as one of the most promising candidates for the next generation of molecular computers, utilizing DNA to execute Boolean logic operations. In recent decades, DNA computing has garnered widespread attention due to its powerful programmable and parallel computing capabilities, demonstrating significant potential in intelligent biological analysis. This review summarizes the latest advancements in DNA logic systems and their biomedical applications. Firstly, it introduces recent DNA logic systems based on various materials such as functional DNA sequences, nanomaterials, and three-dimensional DNA nanostructures. The material innovations driving DNA computing have been summarized, highlighting novel molecular reactions and analytical performance metrics like efficiency, sensitivity, and selectivity. Subsequently, it outlines the biomedical applications of DNA computing-based multi-biomarker analysis in cellular imaging, clinical diagnosis, and disease treatment. Additionally, it discusses the existing challenges and future research directions for the development of DNA computing.

Graphical abstract: Advancements in DNA computing: exploring DNA logic systems and their biomedical applications

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Article information

Article type
Review Article
Submitted
30 apr 2024
Accepted
03 sep 2024
First published
06 sep 2024

J. Mater. Chem. B, 2024,12, 10134-10148

Advancements in DNA computing: exploring DNA logic systems and their biomedical applications

Y. Zhao, X. Li, Y. Zhou, X. Tian, Y. Miao, J. Wang, L. Huang and F. Meng, J. Mater. Chem. B, 2024, 12, 10134 DOI: 10.1039/D4TB00936C

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