Issue 32, 2024

Construction of axially chiral molecules enabled by photoinduced enantioselective reactions

Abstract

Axially chiral molecular scaffolds are widely found in pharmaceutical molecules, functionalized materials, and chiral ligands. The synthesis of these compounds has garnered considerable interest from both academia and industry. The construction of such molecules, enabled by transition metal catalysis and organocatalysis under thermodynamic conditions, has been extensively studied and well-reviewed. In recent years, photoinduced enantioselective reactions have emerged as powerful methods for the catalytic construction of axial chirality. In this review, we provide an overview of various synthetic strategies for the photoinduced construction of axial chirality, with a specific focus on reaction design and catalytic mechanisms. Additionally, we discuss the limitations of current methods and highlight future directions in this field.

Graphical abstract: Construction of axially chiral molecules enabled by photoinduced enantioselective reactions

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Article information

Article type
Perspective
Submitted
08 jun 2024
Accepted
22 jul 2024
First published
25 jul 2024
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2024,15, 12636-12643

Construction of axially chiral molecules enabled by photoinduced enantioselective reactions

Z. Zhang and L. Dai, Chem. Sci., 2024, 15, 12636 DOI: 10.1039/D4SC03766A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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