Issue 16, 2024

ROS-responsive hydrogels: from design and additive manufacturing to biomedical applications

Abstract

Hydrogels with intricate 3D networks and high hydrophilicity have qualities resembling those of biological tissues, making them ideal candidates for use as smart biomedical materials. Reactive oxygen species (ROS) responsive hydrogels are an innovative class of smart hydrogels, and are cross-linked by ROS-responsive modules through covalent interactions, coordination interactions, or supramolecular interactions. Due to the introduction of ROS response modules, this class of hydrogels exhibits a sensitive response to the oxidative stress microenvironment existing in organisms. Simultaneously, due to the modularity of the ROS-responsive structure, ROS-responsive hydrogels can be manufactured on a large scale through additive manufacturing. This review will delve into the design, fabrication, and applications of ROS-responsive hydrogels. The main goal is to clarify the chemical principles that govern the response mechanism of these hydrogels, further providing new perspectives and methods for designing responsive hydrogel materials.

Graphical abstract: ROS-responsive hydrogels: from design and additive manufacturing to biomedical applications

Article information

Article type
Review Article
Submitted
14 mar 2024
Accepted
16 maj 2024
First published
10 jun 2024

Mater. Horiz., 2024,11, 3721-3746

ROS-responsive hydrogels: from design and additive manufacturing to biomedical applications

M. Pu, H. Cao, H. Zhang, T. Wang, Y. Li, S. Xiao and Z. Gu, Mater. Horiz., 2024, 11, 3721 DOI: 10.1039/D4MH00289J

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