Issue 1, 2023

Catecholase-catalyzed synthesis of wedelolactone, a natural coumestan and its analogs

Abstract

Biocatalysis plays an important role in the synthesis of complex organic molecules. Wedelolactone, a natural coumestan, has been reported to have many bioactive properties. A novel and efficient enzyme obtained from sweet potato juice was used for condensation of 4-hydroxycoumarins with catechols to produce wedelolactone and its structurally diverse analogs in moderate to good yields under mild reaction conditions. Hence, this enzymatic approach creates an opportunity to access many coumestan-based compounds that are potential building blocks for the synthesis of pharmaceutically important molecules.

Graphical abstract: Catecholase-catalyzed synthesis of wedelolactone, a natural coumestan and its analogs

Supplementary files

Article information

Article type
Communication
Submitted
14 nov 2022
Accepted
01 dec 2022
First published
02 dec 2022

Org. Biomol. Chem., 2023,21, 89-92

Catecholase-catalyzed synthesis of wedelolactone, a natural coumestan and its analogs

A. Achari, S. Chatterjee, S. Dey, T. K. Kundu and P. Jaisankar, Org. Biomol. Chem., 2023, 21, 89 DOI: 10.1039/D2OB02081E

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