Issue 100, 2022

NMR methods for the analysis of mixtures

Abstract

NMR spectroscopy is a powerful approach for the analysis of mixtures. Its usefulness arises in large part from the vast landscape of methods, and corresponding pulse sequences, that have been and are being designed to tackle the specific properties of mixtures of small molecules. This feature article describes a selection of methods that aim to address the complexity, the low concentrations, and the changing nature that mixtures can display. These notably include pure-shift and diffusion NMR methods, hyperpolarisation methods, and fast 2D NMR methods such as ultrafast 2D NMR and non-uniform sampling. Examples or applications are also described, in fields such as reaction monitoring and metabolomics, to illustrate the relevance and limitations of different methods.

Graphical abstract: NMR methods for the analysis of mixtures

Article information

Article type
Feature Article
Submitted
13 sep 2022
Accepted
19 okt 2022
First published
02 dec 2022
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2022,58, 13855-13872

NMR methods for the analysis of mixtures

J. Dumez, Chem. Commun., 2022, 58, 13855 DOI: 10.1039/D2CC05053F

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