Issue 1, 2021

Simple primary β-amino alcohols as organocatalysts for the asymmetric Michael addition of β-keto esters to nitroalkenes

Abstract

Simple primary β-amino alcohols act as an efficient organocatalysts in the asymmetric Michael addition of β-keto esters with nitroalkenes affording highly pure chiral Michael adducts. Also, both enantiomers of the adducts were obtained, depending on the specific catalyst used and reaction temperature.

Graphical abstract: Simple primary β-amino alcohols as organocatalysts for the asymmetric Michael addition of β-keto esters to nitroalkenes

Supplementary files

Article information

Article type
Paper
Submitted
23 okt 2020
Accepted
03 dec 2020
First published
22 dec 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 203-209

Simple primary β-amino alcohols as organocatalysts for the asymmetric Michael addition of β-keto esters to nitroalkenes

Z. Begum, H. Sannabe, C. Seki, Y. Okuyama, E. Kwon, K. Uwai, M. Tokiwa, S. Tokiwa, M. Takeshita and H. Nakano, RSC Adv., 2021, 11, 203 DOI: 10.1039/D0RA09041G

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