Issue 3, 2020

Catalysis, kinetics and mechanisms of organo-iridium enantioselective hydrogenation-reduction

Abstract

The synthesis of chiral molecules is of great importance to the pharmaceutical, agrochemical, flavour and fragrance industries. The use of organo-iridium complexes has gained a reputation for its great utility in key enantioselective synthetic procedures. Prime examples include the catalytic reduction of carbonyls and imines; iridium-catalysed allylic substitution and catalysed enantioselective hydrogenation of unsaturated carboxylic acids. Important aspects in these processes are the reaction conditions such as the catalyst loading, metal-ion ligands, the substrate, solvent and the reaction times-all of which can affect the degree of enantioselectivity. Understanding the mechanisms of these hydrogenation/reduction reactions through kinetic and other related studies makes a vital contribution to improving catalytic efficiency.

Graphical abstract: Catalysis, kinetics and mechanisms of organo-iridium enantioselective hydrogenation-reduction

Article information

Article type
Minireview
Submitted
24 okt 2019
Accepted
11 dec 2019
First published
11 dec 2019
This article is Open Access
Creative Commons BY-NC license

Catal. Sci. Technol., 2020,10, 590-612

Catalysis, kinetics and mechanisms of organo-iridium enantioselective hydrogenation-reduction

J. M. Mwansa and M. I. Page, Catal. Sci. Technol., 2020, 10, 590 DOI: 10.1039/C9CY02147G

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